Anti-Human TNFRSF10A Recombinant Antibody (4H6.17.8)
CAT#: TAB-161CQ
This antibody specifically binds to DR4 and is capable of inducing apoptosis, and capable of blocking DR4. The antibody is a blocking DR4 antibody.
Published Data
Gene Expression
FC
Figure 1 The FACS analysis of two anti-DR4 antibodies, 4E7.24.3 ("4E7") and 4H6.17.8 ("4H6") (illustrated by the bold lines) as compared to IgG controls (dotted lines).
Both antibodies recognized the DR4 receptor expressed in human 9D cells.
ELISA
Figure 2 Results of an ELISA testing binding of DR4 antibodies, 4E7.24.3 and 4H6.17.8, to DR4 and to other known Apo-2L receptors referred to as Apo-2, DcR1, and DcR2.
❮
❯
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg
Subcellular Location
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg
Normal Tissue
Figure 5 Small intestine
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg
Normal Tissue
Figure 6 Colon
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
❮
❯
Specifications
- Immunogen
- A soluble DR4 ECD
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- 4H6.17.8
- Applications
- FC, ELISA, Block
- Related Disease
- Lupus, and herpes virus infection
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry, ELISA, Blocking. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; DR4; APO2; CD261; TRAILR1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2
- Gene ID
- 8797
- UniProt ID
- O00220
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for TAB-161CQ. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 4H6.17.8"
- CAT
- Product Name
See other products for "TNFRSF10A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H48 | Anti-Human TNFRSF10A Recombinant Antibody (Mapatumumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 |
| TAB-160CQ | Human Anti-TNFRSF10A Recombinant Antibody (TAB-160CQ) | ELISA, FC | Human IgG |
| TAB-160CQ-S(P) | Human Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (TAB-160CQ-S(P)) | ELISA, FC | Human scFv |
| TAB-160CQ-F(E) | Human Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (TAB-160CQ-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-162CQ | Anti-Human TNFRSF10A Recombinant Antibody (4E7.24.3) | FC, ELISA, Block | |
| TAB-161CQ-S(P) | Anti-Human TNFRSF10A Recombinant Antibody scFv Fragment (4H6.17.8) | ELISA, FC, BL | |
| TAB-162CQ-S(P) | Anti-Human TNFRSF10A Recombinant Antibody scFv Fragment (4E7.24.3) | ELISA, FC, BL | |
| TAB-161CQ-F(E) | Anti-Human TNFRSF10A Recombinant Antibody Fab Fragment (4H6.17.8) | ELISA, FC, BL | |
| TAB-162CQ-F(E) | Anti-Human TNFRSF10A Recombinant Antibody Fab Fragment (4E7.24.3) | ELISA, FC, BL |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2090MZ | Recombinant Mouse Anti-Human TNFRSF10A Antibody (clone 43B353) | WB | Mouse antibody |
| HPAB-J0290-YC | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.1.3) | FC, Apop, Inhib, FuncS | Human IgG |
| HPAB-J0291-YC | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.3.2) | FC, Apop, Inhib, FuncS | Human IgG |
| HPAB-J0292-YC | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.12.2) | FC, Apop, Inhib, FuncS | Human IgG |
| VS-0524-YC2 | Chicken Anti-TNFRSF10A Recombinant Antibody (clone CK-a-DR4_#1-6) | ELISA | Chicken IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2109CQ | Mouse Anti-TNFRSF10A Recombinant Antibody (clone 32A1380) | FC, IHC, Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4466 | Rabbit Anti-TNFRSF10A Recombinant Antibody (clone SI560DS) | ELISA | Rabbit IgG |
| MOR-4467 | Rabbit Anti-TNFRSF10A Recombinant Antibody (clone SI561DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0627-CN | Camelid Anti-TNFRSF10A Recombinant Antibody (HPAB-0627-CN) | ELISA | VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-651-FY-F(E) | Human Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (HPAB-651-FY-F(E)) | ELISA, RIA | Human Fab |
| HPAB-0460-WJ-F(E) | Mouse Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (HPAB-0460-WJ-F(E)) | ELISA | Mouse Fab |
| HPAB-0461-WJ-F(E) | Human Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (HPAB-0461-WJ-F(E)) | ELISA | Humanized Fab |
| HPAB-0412-YJ-F(E) | Mouse Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (HPAB-0412-YJ-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-0413-YJ-F(E) | Human Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (HPAB-0413-YJ-F(E)) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H48 | Afuco™ Anti-TNFRSF10A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H48) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1616-FY-F(E) | Mouse Anti-TNFRSF10A Recombinant Antibody (clone mAY4); scFv Fragment | WB, ELISA | Mouse scFv |
| HPAB-1617-FY-F(E) | Human Anti-TNFRSF10A Recombinant Antibody (clone hAY4); scFv Fragment | WB, ELISA | Humanized scFv |
| HPAB-1618-FY-F(E) | Human Anti-TNFRSF10A Recombinant Antibody (clone Hvh3); scFv Fragment | WB, ELISA | Human scFv |
| HPAB-J0290-YC-S(P) | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.1.3); scFv Fragment | FC, Apop, Inhib, FuncS | Human scFv |
| HPAB-J0291-YC-S(P) | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.3.2); scFv Fragment | FC, Apop, Inhib, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY57 | Human Anti-TNFRSF10A (clone mapatumumab) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC68 | Recombinant Anti-TNFRSF10A Vesicular Antibody, EV Displayed (VS-0425-YC68) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7360 | Anti-TNFRSF10A Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
-CB2006C17L-4.jpg)
Application: WB, ELISA
Application: ELISA, FC, WB, Block
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, Inhib
Application: ELISA, FC, Inhib, IHC-Fr, WB, IP
Application: ELISA, Neut, FuncS
Application: ELISA, Neut
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
