Human Anti-TNFRSF10A (clone mapatumumab) scFv-Fc Chimera
CAT#: VS-0325-FY57
The anti-TNFRSF10A scFv-fc antibody is a recombinant antibody that binds to the TNFRSF10A protein. The scFv-fc format combines the antigen-binding capabilities of a single-chain variable fragment (scFv) with the effector functions of the fragment crystallizable (Fc) region of an immunoglobulin.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg
Subcellular Location
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg
Normal Tissue
Figure 5 Small intestine
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg
Normal Tissue
Figure 6 Colon
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TNFRSF10A
- Species Reactivity
- Human
- Clone
- mapatumumab
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Hirata disease and chondromalacia
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- TNF Receptor Superfamily Member 10a; Tumor Necrosis Factor Receptor Superfamily, Member 10a; TNF-Related Apoptosis-Inducing Ligand Receptor 1; Death Receptor 4; TRAIL Receptor 1; TRAIL-R1; TRAILR1; APO2
- Gene ID
- 8797
- UniProt ID
- O00220
- Long Name
- TNF Receptor Superfamily Member 10a
- Cellular Localization
- Cell membrane; Membrane raft; Cytoplasm, cytosol
- Post Translation Modifications
- Palmitoylated.
Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death.
Palmitoylated by ZDHHC3.
Glycosylation at Asn156
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 9 sites, 1 N-linked glycan (1 site), 3 O-linked glycans (5 sites)
- Protein Refseq
- NP_003835.3
- Function
- TNFRSF10A (TNF receptor superfamily member 10A), also known as DR4, is a death receptor involved in apoptosis. It is part of the extrinsic apoptosis pathway and is a target for cancer therapy.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-160CQ | Human Anti-TNFRSF10A Recombinant Antibody (TAB-160CQ) | ELISA, FC | Human IgG |
| TAB-160CQ-S(P) | Human Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (TAB-160CQ-S(P)) | ELISA, FC | Human scFv |
| TAB-160CQ-F(E) | Human Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (TAB-160CQ-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-161CQ | Anti-Human TNFRSF10A Recombinant Antibody (4H6.17.8) | FC, ELISA, Block | |
| TAB-161CQ-S(P) | Anti-Human TNFRSF10A Recombinant Antibody scFv Fragment (4H6.17.8) | ELISA, FC, BL | |
| TAB-162CQ-S(P) | Anti-Human TNFRSF10A Recombinant Antibody scFv Fragment (4E7.24.3) | ELISA, FC, BL | |
| TAB-161CQ-F(E) | Anti-Human TNFRSF10A Recombinant Antibody Fab Fragment (4H6.17.8) | ELISA, FC, BL | |
| TAB-162CQ-F(E) | Anti-Human TNFRSF10A Recombinant Antibody Fab Fragment (4E7.24.3) | ELISA, FC, BL |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2090MZ | Recombinant Mouse Anti-Human TNFRSF10A Antibody (clone 43B353) | WB | Mouse antibody |
| HPAB-0412-YJ | Mouse Anti-TNFRSF10A Recombinant Antibody (HPAB-0412-YJ) | ELISA, FuncS, FC | Mouse IgG |
| HPAB-0413-YJ | Human Anti-TNFRSF10A Recombinant Antibody (HPAB-0413-YJ) | ELISA, FuncS, FC | Chimeric (Mouse/Human) IgG1 |
| HPAB-J0290-YC | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.1.3) | FC, Apop, Inhib, FuncS | Human IgG |
| HPAB-J0291-YC | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.3.2) | FC, Apop, Inhib, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2109CQ | Mouse Anti-TNFRSF10A Recombinant Antibody (clone 32A1380) | FC, IHC, Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4466 | Rabbit Anti-TNFRSF10A Recombinant Antibody (clone SI560DS) | ELISA | Rabbit IgG |
| MOR-4467 | Rabbit Anti-TNFRSF10A Recombinant Antibody (clone SI561DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0627-CN | Camelid Anti-TNFRSF10A Recombinant Antibody (HPAB-0627-CN) | ELISA | VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-651-FY-F(E) | Human Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (HPAB-651-FY-F(E)) | ELISA, RIA | Human Fab |
| HPAB-1616-FY-S(P) | Mouse Anti-TNFRSF10A Recombinant Antibody (clone mAY4); Fab Fragment | WB, ELISA | Mouse Fab |
| HPAB-1617-FY-S(P) | Human Anti-TNFRSF10A Recombinant Antibody (clone hAY4); Fab Fragment | WB, ELISA | Humanized Fab |
| HPAB-1618-FY-S(P) | Human Anti-TNFRSF10A Recombinant Antibody (clone Hvh3); Fab Fragment | WB, ELISA | Human Fab |
| HPAB-J0290-YC-F(E) | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.1.3); Fab Fragment | FC, Apop, Inhib, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H48 | Afuco™ Anti-TNFRSF10A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H48) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0460-WJ-S(P) | Mouse Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (HPAB-0460-WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-0461-WJ-S(P) | Human Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (HPAB-0461-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0412-YJ-S(P) | Mouse Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (HPAB-0412-YJ-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-0413-YJ-S(P) | Mouse Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (HPAB-0413-YJ-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-1616-FY-F(E) | Mouse Anti-TNFRSF10A Recombinant Antibody (clone mAY4); scFv Fragment | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC68 | Recombinant Anti-TNFRSF10A Vesicular Antibody, EV Displayed (VS-0425-YC68) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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