Human Anti-TNFRSF10A (clone mapatumumab) scFv-Fc Chimera

Name: Human Anti-TNFRSF10A (clone mapatumumab) scFv-Fc Chimera
SKU: VS-0325-FY57
Rating: 5 (1 reviews)

CAT#: VS-0325-FY57

The anti-TNFRSF10A scFv-fc antibody is a recombinant antibody that binds to the TNFRSF10A protein. The scFv-fc format combines the antigen-binding capabilities of a single-chain variable fragment (scFv) with the effector functions of the fragment crystallizable (Fc) region of an immunoglobulin.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A549

Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg

Subcellular Location Figure 3 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg

Subcellular Location Figure 4 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg

Normal Tissue Figure 5 Small intestine

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg

Normal Tissue Figure 6 Colon

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg

Normal Tissue Figure 7 Kidney

Cells in glomeruli
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A

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Specifications

Host Species
Human

Type
Human IgG1, scFv-Fc

Antibody Isotype
scFv-Fc

Specificity
Human TNFRSF10A

Species Reactivity
Human

Clone
mapatumumab

Applications
ELISA, Flow Cytometry

Related Disease
Hirata disease and chondromalacia

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Target

Alternative Names
TNF Receptor Superfamily Member 10a; Tumor Necrosis Factor Receptor Superfamily, Member 10a; TNF-Related Apoptosis-Inducing Ligand Receptor 1; Death Receptor 4; TRAIL Receptor 1; TRAIL-R1; TRAILR1; APO2

Gene ID
8797

UniProt ID
O00220

Long Name
TNF Receptor Superfamily Member 10a

Cellular Localization
Cell membrane; Membrane raft; Cytoplasm, cytosol

Post Translation Modifications
Palmitoylated.
Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death.
Palmitoylated by ZDHHC3.
Glycosylation at Asn156
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 9 sites, 1 N-linked glycan (1 site), 3 O-linked glycans (5 sites)

Protein Refseq
NP_003835.3

Function
TNFRSF10A (TNF receptor superfamily member 10A), also known as DR4, is a death receptor involved in apoptosis. It is part of the extrinsic apoptosis pathway and is a target for cancer therapy.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0325-FY57.pdf

MSDS

MSDS - VS-0325-FY57.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Isotype Control

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