Anti-Human TNFRSF10A Recombinant Antibody Fab Fragment (4H6.17.8)

Name: Anti-Human TNFRSF10A Recombinant Antibody Fab Fragment (4H6.17.8)
SKU: TAB-161CQ-F(E)
Rating: 5 (1 reviews)

CAT#: TAB-161CQ-F(E)

This antibody Fab Fragment specifically binds to DR4 and is capable of inducing apoptosis, and capable of blocking DR4.

Gene Expression

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A

Subcellular Location Figure 1 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A549

Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg

Subcellular Location Figure 3 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg

Subcellular Location Figure 4 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg

Normal Tissue Figure 5 Small intestine

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg

Normal Tissue Figure 6 Colon

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg

Normal Tissue Figure 7 Kidney

Cells in glomeruli
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

❮

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Specifications

Immunogen
A soluble DR4 ECD

Host Species
Mouse

Antibody Isotype
IgG1

Specificity
Human

Species Reactivity
Human

Clone
4H6.17.8

Applications
Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Flow Cytometry; Blocking

Related Disease
Lupus, and herpes virus infection

Target

Alternative Names
TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; DR4; APO2; CD261; TRAILR1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2

Gene ID
8797

UniProt ID
O00220

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-161CQ-F(E).pdf

MSDS

MSDS - TAB-161CQ-F(E).pdf

COA

Certificate of Analysis Lookup

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