Afuco™ Anti-TNFRSF10A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H48) (CAT#: AFC-TAB-H48)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human TNFRSF10A. It is an experimental human monoclonal antibody for the treatment of cancer.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg
Figure 2 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg
Figure 3 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg
Figure 5 Small intestine
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg
Figure 6 Colon
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg
Figure 7 Kidney
(Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg
(Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
Specifications
- Host Species
- Human
- Derivation
- human
- Type
- ADCC enhanced antibody
- Specificity
- TNFRSF10A(tumor necrosis factor receptor (TNFR) superfamily member 10A, death receptor 4, DR4, TNF-related apoptosis-inducing ligand receptor 1, TRAILR1, TRAIL-R1, TR-1, CD261) agonistic antibody [Homo sapiens]
- Species Reactivity
- Human
- Applications
- Neut, ELISA, IF, IP, FuncS, FC
- Conjugate
- Unconjugated
- Generic Name
- Mapatumumab
- Related Disease
- Colorectal cancers
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1; TRAIL-R1; TRAIL receptor 1; death receptor 4
- Gene ID
- 8797
- UniProt ID
- O00220
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "mapatumumab"
Anti-Human TNFRSF10A Recombinant Antibody (Mapatumumab)Recombinant human antibody to Human TNFRSF10A. Mapatumumab (HGS-ETR1) is an experimental human monoclonal antibody for the treatment of cancer.
DrugMonitor™ Anti-Mapatumumab Antibody (VS-1224-YC710)Mapatumumab is a fully human agonistic monoclonal antibody targeting TRAIL-R1, currently undergoing clinical trials for cancer treatment, including relapsed or refractory non-Hodgkin's lymphoma (NHL). The DrugMonitor™ Anti-Mapatumumab Antibody (VS-1224-YC710) is an anti-drug antibody (ADA) against Mapatumumab. This drug-based antibody is raised in mice immunized with the Mapatumumab. The anti-Mapatumumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Mapatumumab in samples.
See other products for "TNFRSF10A"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1242z | Mouse Anti-TNFRSF10A Recombinant Antibody (clone 27A12) | WB, FC, IHC, Neut | Mouse IgG1 |
| HPAB-J0290-YC | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.1.3) | FC, Apop, Inhib, FuncS | Human IgG |
| HPAB-J0291-YC | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.3.2) | FC, Apop, Inhib, FuncS | Human IgG |
| HPAB-J0292-YC | Human Anti-TNFRSF10A Recombinant Antibody (clone 7.12.2) | FC, Apop, Inhib, FuncS | Human IgG |
| VS-0524-YC2 | Chicken Anti-TNFRSF10A Recombinant Antibody (clone CK-a-DR4_#1-6) | ELISA | Chicken IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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