Anti-Human TNFRSF10A Recombinant Antibody Fab Fragment (4E7.24.3) (CAT#: TAB-162CQ-F(E))
The antibody binds to DR4, but not to any of the other Apo-2L receptors, Apo-2, DcRl, or DcR2. It can be potentially used in the treatment of various diseases and pathological conditions, including cancer.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg
Figure 2 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg
Figure 3 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg
Figure 5 Small intestine
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg
Figure 6 Colon
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg
Figure 7 Kidney
(Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg
(Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
Specifications
- Immunogen
- A soluble DR4 ECD
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- 4E7.24.3
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Flow Cytometry; Blocking
- Related Disease
- Lupus, herpes virus infection and so on
Target
- Alternative Names
- TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; DR4; APO2; CD261; TRAILR1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2
- Gene ID
- 8797
- UniProt ID
- O00220
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1242z | Mouse Anti-TNFRSF10A Recombinant Antibody (clone 27A12) | WB, FC, IHC, Neut | Mouse IgG1 |
| MOB-2090MZ | Recombinant Mouse Anti-Human TNFRSF10A Antibody (clone 43B353) | WB | Mouse antibody |
| FN-011CQ | Mouse Anti-TNFRSF10A Recombinant Antibody (clone HS101) | FC, Inhib, ICC, IP | Mouse IgG1 |
| HPAB-0412-YJ | Mouse Anti-TNFRSF10A Recombinant Antibody (HPAB-0412-YJ) | ELISA, FuncS, FC | Mouse IgG |
| HPAB-0413-YJ | Human Anti-TNFRSF10A Recombinant Antibody (HPAB-0413-YJ) | ELISA, FuncS, FC | Chimeric (Mouse/Human) IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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