Human Anti-TNFRSF12A Recombinant Antibody (clone TPP-2195) (CAT#: HPAB-0056-LSX)
Recombinant monoclonal antibody to TWEAKR. Clone TPP-2195 is a humanized antibody that can be potentially used in the treatment of tumors and other disorders and conditions associated with expression of the TWEAKR.
Specific Inquiry
ELISA
Figure 1 Interaction of TWEAKR ectodomain with antibodies and reference antibodies.
Shown is the result of an ELISA with TWEAKR-Fc fusion protein (TPP-2202) coating (1 mg/ml) and 0.08 mg/ml (open bars) and 0.3 mg/ml (filled bars) of biotinylated IgG as soluble binding partner. Detection was done with Streptavidin-HRP and Amplex-Red substrate. Y is "ELISA signal intensity [Rfu]"; X are "antibody constructs tested": a is "TPP-2090"; b is "TPP-2084"; c is "PDL-192(TPP-1104)"; d is "P4A8(TPP-1324)"; e is "P3G5(TPP-2195)"; f is "136.1(TPP-2194)"; h is "ITEM1"; i is "ITEM4"; j is a murine isotype control; k is a human isotype control. All tested antibodies show saturated binding with a concentration of 80 ng/ml.
ELISA
Figure 2 Interaction of TWEAKR cysteine rich domain with antibodies and reference antibodies.
Shown is the result of an ELISA with TWEAKR(34-68)-Fc fusion protein (TPP-2203) coating (1 mg/ml) and 0.08 mg/ml (open bars) and 0.3 mg/ml (filled bars) of biotinylated IgG as soluble binding partner. Detection was done with Streptavidin-HRP and Amplex-Red substrate. Y is "ELISA signal intensity [Rfu]"; X are "antibody constructs tested": a is "TPP-2090"; b is "TPP-2084"; c is "PDL-192(TPP-1104)"; d is "P4A8(TPP-1324)"; e is "P3G5(TPP-2195)"; f is "136.1(TPP-2194)"; h is "ITEM1"; i is "ITEM4"; j is a murine isotype control; k is a human isotype control. The antibodies bind to the cysteine rich domain.
Specifications
- Immunogen
- Dimeric Fc-fused extracellular domains of human and murine TWEAK
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Human TNFRSF12A
- Species Reactivity
- Human
- Clone
- TPP-2195
- Applications
- ELISA, WB, FC
- Related Disease
- Tumors and other disorders and conditions associated with expression of the TWEAKR
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay (80 ng/ml).
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Immunotoxin Products
Human Antibody Products
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ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G061G | Anti-TNFRSF12A immunotoxin ITEM-4 (scFv)-Gel | Cytotoxicity assay, Function study |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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