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    TNFRSF12A

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    Anti-TNFRSF12A Products

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    For Research Use Only. Not For Clinical Use.


    Background

    The tumor-necrosis factor (TNF)-related cytokines are a superfamily of proteins that have an array of functions, including ones implicated in immune regulation and apoptosis regulation. TWEAK (TNF-like weak inducer of apoptosis) is one member of this superfamily. Fnl4, a TWEAK receptor, is a growth factor-regulated immediate-early response gene that decreases cellular adhesion to the extracellular matrix and reduces serum-stimulated growth and migration.
    Protein class

    Cancer-related genes, CD markers

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Basal prostatic cells, Pancreatic endocrine cells, Ductal cells, Prostatic glandular cells, Exocrine glandular cells, Urothelial cells, Basal respiratory cells, Basal keratinocytes)

    Immune cell specificity

    Group enriched (eosinophil, neutrophil)

    Cell line specificity

    Cell line enhanced (U-251 MG)

    Interaction

    Associates with TRAF1 and TRAF2, and probably also with TRAF3.

    Molecular function

    Developmental protein, Receptor

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