Anti-TfR Antibody-Cytokine Fusion Protein, IgG (ch17217)-IL2 (CAT#: ACFP-SH023)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TfR IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TfR as well as the biological activity of IL2. This antibody-cytokine fusion protein can potentially be used against different tumor types due to TfR overexpression in a wide variety of cancer malignances. This immunocytokine was designed for treating TfR overexpression cancer malignances.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Target
  • TfR
  • Molecule Class
  • IgG2b-IL2
  • Species Reactivity
  • Mouse
  • Expression Host
  • CHO
  • Clone
  • ch17217
  • Related Disease
  • TfR overexpression cancer malignances
  • Cytokine 1
  • IL2
  • Cytokines 1 Description
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
  • Cytokine 1 Species
  • Mouse
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1

Downloads

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See other products for "Clone ch17217"

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Immunotoxin

CAT Product Name Application Type
AGTO-G067E Anti-TFRC immunotoxin HB21 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G067D Anti-TFRC immunotoxin HB21 (scFv)-DT Cytotoxicity assay, Function study
AGTO-G067G Anti-TFRC immunotoxin HB21 (scFv)-Gel Cytotoxicity assay, Function study
AGTO-G067R Anti-TFRC immunotoxin HB21 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G067S Anti-TFRC immunotoxin HB21 (scFv)-Sap Cytotoxicity assay, Function study

Blocking Antibody

CAT Product Name Application Type
NEUT-1999CQ Rat Anti-Tfrc Recombinant Antibody (clone RI7217) FC, ICC, IP, WB, Block Rat IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3548 Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) FC, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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