IL-18-DT immunotoxin (CAT#: AGTO-G042D)

This immunotoxin was achieved by conjugating/fusing the IL-18 to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to IL-18R–bearing antigen-presenting cells (APCs) and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of Experimental autoimmune encephalomyelitis (EAE).


Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Mouse
  • Molecule Class
  • IL-18-DT
  • Toxin Description
  • Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Experimental autoimmune encephalomyelitis (EAE)

Target

  • Alternative Names
  • IL18R1; interleukin 18 receptor 1; Il1rrp; Il18ralpha; interleukin-18 receptor 1; IL-18R1; IL-1Rrp; IL1R-rp; IL-18R-1; IL1 receptor-related protein; CD218 antigen-like family member A; interleukin 1 receptor related protein; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB422

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G042E IL-18-PE immunotoxin Cytotoxicity assay, Function study

Humanized Antibody

CAT Product Name Application Type
TAB-211CT Human Anti-IL18R1 Recombinant Antibody (TAB-211CT) FC, ELISA, Ibhibition Humanized antibody
TAB-211CT-S(P) Human Anti-IL18R1 Recombinant Antibody; scFv Fragment (TAB-211CT-S(P)) FC, ELISA, Ibhibition Humanized scFv
TAB-211CT-F(E) Human Anti-IL18R1 Recombinant Antibody; Fab Fragment (TAB-211CT-F(E)) FC, ELISA, Ibhibition Humanized Fab

Neutralizing Antibody

Rabbit Monoclonal Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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