Anti-PSMA (MLN591)-vc-MMAE ADC (CAT#: ADC-152LCT)
This ADC product is composed of an anti-PSMA antibody (clone MLN591) conjuagated via a vc linker to MMAE (MLN591-vc-MMAE). It has demonstrated a response in HRPC treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Kidney
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
Figure 2 Prostate
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
Specifications
- Antibody Overview
- Mouse monoclonal Antibody MLN591 (Anti-PSMA)
- Clone
- MLN591
- Antibody Isotype
- IgG1
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
- Alternative Names
- FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I;
- Gene ID
- 2346
- UniProt ID
- Q04609
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1169z | Mouse Anti-FOLH1 Recombinant Antibody (MOB-1169z) | WB, FC, IHC, ICC, CyTOF | Mouse IgG2a |
| HPAB-J0213-YC | Mouse Anti-FOLH1 Recombinant Antibody (HPAB-J0213-YC) | ELISA, IHC (0.3µg/mL), FuncS | Mouse IgG |
| HPAB-J0214-YC | Mouse Anti-FOLH1 Recombinant Antibody (HPAB-J0214-YC) | ELISA, IHC (0.3µg/mL) | Mouse IgG |
| HPAB-J0215-YC | Human Anti-FOLH1 Recombinant Antibody (HPAB-J0215-YC) | ELISA, WB, FuncS | Chimeric (mouse/human) IgG1 |
| HPAB-1248WJ | Human Anti-FOLH1 Recombinant Antibody (clone 3D8) | FC | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1169z-S(P) | Recombinant Anti-Human FOLH1 Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| HPAB-1154WJ-S(P) | Mouse Anti-FOLH1 Recombinant Antibody (clone E99); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1248WJ-S(P) | Human Anti-FOLH1 Recombinant Antibody (clone 3D8); scFv Fragment | ELISA | Human scFv |
| HPAB-1249WJ-S(P) | Human Anti-FOLH1 Recombinant Antibody (clone 4D4); scFv Fragment | ELISA | Human scFv |
| HPAB-S0115-YC-S(P) | Human Anti-FOLH1 Recombinant Antibody (clone V5); scFv Fragment | ELISA | Human scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-066 | Recombinant Anti-Human FOLH1 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-277CT | Anti-Human PSMA Therapeutic Single Domain Single Domain Antibody (C3) | ELISA | Single domain antibody |
| HPAB-M0386-YC | Recombinant Camelid Anti-FOLH1 Single Domain Antibody (M/YC-1) | ELISA | Camelid VHH |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-018 | Anti-Human PMSA Recombinant Antibody (Capromab Pendetide) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-274CT | Mouse Anti-FOLH1 Recombinant Antibody (TAB-274CT) | FC, IA, IHC, Inhib, IB, IF, WB, ELISA | Mouse IgG2a |
| TAB-275CT | Mouse Anti-FOLH1 Recombinant Antibody (TAB-275CT) | ICC, FC, Block, IB, IF, IHC, Inhib, WB, ELISA | Mouse IgG1 |
| TAB-276CT | Mouse Anti-FOLH1 Recombinant Antibody (TAB-276CT) | IB, FC, IF, Inhib, WB, ELISA, IHC | Mouse IgG2b |
| TAB-274CT-S(P) | Mouse Anti-FOLH1 Recombinant Antibody; scFv Fragment (TAB-274CT-S(P)) | WB, ELISA, FC, IF, IHC | Mouse scFv |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G029E | Anti-FOLH1 immunotoxin D7 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G029D | Anti-FOLH1 immunotoxin D7 (scFv)-DT | Cytotoxicity assay, Function study |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC072 | PE-A*02:01/Human PSMA (VLAGGFFLL) MHC Tetramer | FCM | |
| MHC-LC073 | APC-A*02:01/Human PSMA (VLAGGFFLL) MHC Tetramer | FCM | |
| MHC-LC074 | BV421-A*02:01/Human PSMA (VLAGGFFLL) MHC Tetramer | FCM | |
| MHC-LC2502 | PE-B*07:02/Human FOLH1 (LPSIPVHPI) MHC Tetramer | FCM | |
| MHC-YF277 | A*02:01/Human PSMA (VLAGGFFLL) MHC Monomer | MHC Multimer |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1332 | Hi-Affi™ Rabbit Anti-FOLH1 Recombinant Antibody (clone DS1332AB) | IHC-P | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0656-CN-F(E) | Mouse Anti-FOLH1 Recombinant Antibody; Fab Fragment (HPAB-0656-CN-F(E)) | WB, IF, FC | Mouse Fab |
| HPAB-M0092-YC-F(E) | Mouse Anti-FOLH1 Recombinant Antibody (clone 10B3); Fab Fragment | FC | Mouse Fab |
| HPAB-M0093-YC-F(E) | Human Anti-FOLH1 Recombinant Antibody (clone h10B3); Fab Fragment | FC | Humanized Fab |
| HPAB-1130WJ-F(E) | Mouse Anti-FOLH1 Recombinant Antibody (clone J415); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1154WJ-F(E) | Mouse Anti-FOLH1 Recombinant Antibody (clone E99); Fab Fragment | ELISA | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-018 | Afuco™ Anti-FOLH1 ADCC Recombinant Antibody (Capromab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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