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FOLH1

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This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, WB
Target:
PSMA
Linker:
VC (valine-citrulline)
Drug:
MMAE (Monomethyl auristatin E)
Target:
PSMA
Linker:
mc-VC (maleimidocaproyl-valine-citrulline)
Drug:
MMAE (Monomethyl auristatin E)
Target:
PSMA
Linker:
thioester
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
PSMA
Linker:
VC (valine-citrulline)
Drug:
MMAE (monomethyl auristatin E)
Target:
PSMA
Linker:
SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
Drug:
DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Derivation:
Mouse immuniezd library
Species Reactivity:
Human
Application:
WB, ELISA, FC, IF, IHC
Derivation:
Mouse immuniezd library
Species Reactivity:
Human
Application:
WB, ELISA, FC, IF, IHC
Derivation:
Mouse immuniezd library
Species Reactivity:
Human
Application:
WB, ELISA, FC, IF, IHC
Derivation:
Llama immuniezd VHH library
Species Reactivity:
Human
Type:
Single domain antibody
Application:
ELISA
Derivation:
mAb L-186 hybridoma cell lines
Species Reactivity:
Human
Application:
WB, ELISA, IP, IF
Derivation:
Mouse hybridoma cell lines
Species Reactivity:
Human
Application:
WB, ELISA, IHC, IF, FC
Species Reactivity:
Human
Type:
Llama VHH
Application:
ELISA, IHC, FC, FuncS
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Derivation:
Mouse hybridoma cell lines
Species Reactivity:
Human
Application:
ELISA, FC
Derivation:
Mouse hybridoma cell lines
Species Reactivity:
Human
Application:
ELISA, FC
Derivation:
Mouse hybridoma cell lines
Species Reactivity:
Human
Application:
ELISA, FC
Derivation:
Mouse immuniezd library
Species Reactivity:
Human
Application:
WB, ELISA, FC, IF, IHC
Derivation:
Mouse immuniezd library
Species Reactivity:
Human
Application:
WB, ELISA, FC, IF, IHC
Derivation:
Mouse immuniezd library
Species Reactivity:
Human
Application:
WB, ELISA, FC, IF, IHC
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