SmartAb™ Recombinant Anti-FOLH1 pH-dependent Antibody (VS-0825-YC139)
CAT#: VS-0825-YC139
The anti-FOLH1 pH-dependent antibody (VS-0825-YC139) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to human FOLH1. By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for FOLH1 under acidic conditions compared to physiological pH. Using a yeast surface display system with pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from FOLH1 at pH 6.0. This pH-sensitive antibody retains its binding affinity for FOLH1 on tumor cells while exhibiting negligible binding to the receptor on normal cells at physiological pH. Human FOLH1, or Folate Hydrolase 1, also known as PSMA (Prostate-Specific Membrane Antigen), is a transmembrane enzyme. It is highly expressed on prostate cancer cells and on the vasculature of various other solid tumors, making it a prominent target for cancer imaging and therapy.
Gene Expression
Normal Tissue
Figure 1 Kidney
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
Normal Tissue
Figure 2 Prostate
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
❮
❯
Specifications
- Immunogen
- Irradiated PSMA transfected Sp2/0 Ag14 cells.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human FOLH1
- Species Reactivity
- Human
- Applications
- FC
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
- Alternative Names
- Folate Hydrolase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folylpoly-Gamma-Glutamate Carboxypeptidase; Cell Growth-Inhibiting Gene 27 Protein; Membrane Glutamate Carboxypeptidase; Glutamate Carboxypeptidase II; Glutamate Carboxypeptidase 2; Glutamate Carboxylase II; EC 3.4.17.21; NAALADase I; NAALAD1; GCPII;
- Gene ID
- 2346
- UniProt ID
- Q04609
- Long Name
- Folate Hydrolase 1
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-1249WJ-F(E) | Human Anti-FOLH1 Recombinant Antibody (clone 4D4); Fab Fragment | ELISA | Human Fab |
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