Human Anti-FOLH1 (clone V5) scFv-Fc Chimera (CAT#: VS-0425-FY109)

• Immunogen
• The immunogen used to screen for the antibody was the extracellular region of recombinant human prostate-specific membrane antigen (PSMA).

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• The antibody is designed to be specific for the extracellular region of human prostate-specific membrane antigen (PSMA).

• Species Reactivity
• Human

• Clone
• V5

• Applications
• ELISA

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• ELISA: 1ug/mL-1pg/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Folate Hydrolase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folylpoly-Gamma-Glutamate Carboxypeptidase; Cell Growth-Inhibiting Gene 27 Protein; Membrane Glutamate Carboxypeptidase; Glutamate Carboxypeptidase II; Glutamate Carboxypeptidase 2; Glutamate Carboxylase II; EC 3.4.17.21; NAALADase I; NAALAD1; GCPII

• Gene ID
• 2346

• UniProt ID
• Q04609

• Long Name
• Folate Hydrolase 1

• Sequence Similarities
• Belongs to the peptidase M28 family. M28B subfamily.

• Cellular Localization
• Cell membrane, Cytoplasm, Membrane

• Post Translation Modifications
• The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
  The N-terminus is blocked.
  Glycosylation at Asn76, Asn336, Asn51, Asn121, Asn140, Asn153, Asn195, Asn459, Asn476, and Asn638
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 13 sites

• Protein Refseq
• XP_011518260.2; XP_016872921.1; XP_016872922.1; XP_016872923.1; XP_047282634.1

• Function
• Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
  Also exhibits a dipeptidyl-peptidase IV type activity. in vitro, cleaves Gly-Pro-AMC.

• HPAB-S0115-YC
• Human Anti-FOLH1 Recombinant Antibody (clone V5)

• HPAB-S0115-YC-F(E)
• Human Anti-FOLH1 Recombinant Antibody (clone V5); Fab Fragment

• HPAB-S0115-YC-S(P)
• Human Anti-FOLH1 Recombinant Antibody (clone V5); scFv Fragment

• HPAB-S0115-YC-mRNA
• Human Anti-FOLH1 Antibody (clone V5), mRNA

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