Human Anti-FOLH1 (clone V5) scFv-Fc Chimera
CAT#: VS-0425-FY109
This scFv-Fc construct targets FOLH1 (Folate hydrolase 1), also known as PSMA (Prostate-specific membrane antigen). By targeting FOLH1, it offers a potential therapeutic strategy for prostate cancer and other diseases where FOLH1 is overexpressed.
Gene Expression
Normal Tissue
Figure 1 Kidney
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
Normal Tissue
Figure 2 Prostate
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
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Specifications
- Immunogen
- The immunogen used to screen for the antibody was the extracellular region of recombinant human prostate-specific membrane antigen (PSMA).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The antibody is designed to be specific for the extracellular region of human prostate-specific membrane antigen (PSMA).
- Species Reactivity
- Human
- Clone
- V5
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 1ug/mL-1pg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Folate Hydrolase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folylpoly-Gamma-Glutamate Carboxypeptidase; Cell Growth-Inhibiting Gene 27 Protein; Membrane Glutamate Carboxypeptidase; Glutamate Carboxypeptidase II; Glutamate Carboxypeptidase 2; Glutamate Carboxylase II; EC 3.4.17.21; NAALADase I; NAALAD1; GCPII
- Gene ID
- 2346
- UniProt ID
- Q04609
- Long Name
- Folate Hydrolase 1
- Sequence Similarities
- Belongs to the peptidase M28 family. M28B subfamily.
- Cellular Localization
- Cell membrane, Cytoplasm, Membrane
- Post Translation Modifications
- The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
The N-terminus is blocked.
Glycosylation at Asn76, Asn336, Asn51, Asn121, Asn140, Asn153, Asn195, Asn459, Asn476, and Asn638
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 13 sites
- Protein Refseq
- XP_011518260.2; XP_016872921.1; XP_016872922.1; XP_016872923.1; XP_047282634.1
- Function
- Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
Also exhibits a dipeptidyl-peptidase IV type activity. in vitro, cleaves Gly-Pro-AMC.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
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| MHC-CN0679 | FITC-A*02:01/Human FOLH1 (MMNDQLMFL) MHC Tetramer | FCM, IHC | |
| MHC-CN0680 | A*02:01/Human FOLH1 (MMNDQLMFL) MHC Tetramer | FCM, IHC | |
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