PE-A*02:01/Human INS (AQWGPDPAAA) MHC Tetramer
CAT#: MHC-LC905
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of INS-derived peptide of AQWGPDPAAA covering 15-24 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Pancreas
Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (EFO-21, U-2 OS, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS
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Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- INS
- Antigen Species
- Human
- Peptide
- AQWGPDPAAA
- Range
- 15-24
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
- Alternative Names
- INS; insulin; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
- Gene ID
- 3630
- UniProt ID
- P01308
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Related Diseases
Maturity Onset Diabetes of the Young
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "INS"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1554-VHH | Recombinant Anti-human INS VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0152MZ | Recombinant Mouse Anti-Insulin/Proinsulin Antibody (clone E7C5) | ELISA, IHC-Fr | Mouse antibody |
| FAMAB-0182YC | Mouse Anti-INS Recombinant Antibody (clone 123) | ELISA | Mouse IgG1 |
| FAMAB-0183YC | Mouse Anti-INS Recombinant Antibody (clone 124) | ELISA | Mouse IgG2a |
| FAMAB-0184YC | Mouse Anti-INS Recombinant Antibody (clone 133) | ELISA | Mouse IgG2a |
| FAMAB-0185YC | Mouse Anti-INS Recombinant Antibody (clone 125) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1684 | BV421-A*02:01/Human INS (ALWGPDPAAA) MHC Tetramer | FCM | |
| MHC-CN0909 | PE-DRB1*04:01/Human INS (GAGSLQPLALEGSLQKRG) MHC Tetramer | FCM, IHC | |
| MHC-CN0910 | APC-DRB1*04:01/Human INS (GAGSLQPLALEGSLQKRG) MHC Tetramer | FCM, IHC | |
| MHC-CN0911 | FITC-DRB1*04:01/Human INS (GAGSLQPLALEGSLQKRG) MHC Tetramer | FCM, IHC | |
| MHC-CN0912 | DRB1*04:01/Human INS (GAGSLQPLALEGSLQKRG) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1841 | Rabbit Anti-INS Recombinant Antibody (clone DS1841AB) | IHC-P, WB | Rabbit IgG |
| MOR-4627 | Rabbit Anti-INS Recombinant Antibody (clone TH140DS) | IF, ICC, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0182-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 123); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0183-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 124); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0184-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 133); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0185-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 125); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0186-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 127); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0182-YC-F(E) | Mouse Anti-INS Recombinant Antibody (clone 123); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0183-YC-F(E) | Mouse Anti-INS Recombinant Antibody (clone 124); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0184-YC-F(E) | Mouse Anti-INS Recombinant Antibody (clone 133); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0185-YC-F(E) | Mouse Anti-INS Recombinant Antibody (clone 125); Fab Fragment | ELISA | Mouse Fab |
| PFBS-0026 | Anti-INS Recombinant Antibody (Clone 5ins16); Fab Fragment | ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF029 | DRB1*04:01/Human Proinsulin (GAGSLQPLALEGSLQKRG) MHC Monomer | MHC Multimer | |
| MHC-YF032 | DRB1*04:01/Human Proinsulin (GIVEQCCTSICSLYQ) MHC Monomer | MHC Multimer | |
| MHC-YF236 | A*02:01/Human Ins B. 10 (HLVEALYLV) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3566 | Anti-INS Immunohistochemistry Kit | IHC | |
| VS-0525-XY3567 | Anti-Mouse INS Immunohistochemistry Kit | IHC | |
| VS-0525-XY3568 | Anti-Rat INS Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC112 | Recombinant Anti-INS (α chain x β chain) Biparatopic Antibody, Tandem scFv (Clone AE9D6 x Clone CB5) | ELISA | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC195 | Recombinant Anti-INS Eliminating Antibody, pH-Sensitive (5ins16 var.) | Antigen-Sweeping In Vivo. | Human IgG |
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