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INS

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After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
AQWGPDPAAA
Conjugate:
PE
Class:
Class II
Target:
INS
Specificity:
Human
Peptide:
GSLQPLALEGSLQKRG
Conjugate:
PE
Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
LYLVCGERG
Conjugate:
PE
Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
LYLVCGERV
Conjugate:
PE
Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
LYLVCGERGF
Conjugate:
PE
Class:
Class II
Target:
INS
Specificity:
Human
Peptide:
LVEALYLVCGERGG
Conjugate:
PE
Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
ALWGPDPAAA
Conjugate:
PE
Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
AQWGPDPAAA
Conjugate:
APC
Class:
Class II
Target:
INS
Specificity:
Human
Peptide:
GSLQPLALEGSLQKRG
Conjugate:
APC
Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
LYLVCGERG
Conjugate:
APC
Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
LYLVCGERV
Conjugate:
APC
Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
LYLVCGERGF
Conjugate:
APC
Class:
Class II
Target:
INS
Specificity:
Human
Peptide:
LVEALYLVCGERGG
Conjugate:
APC
Class:
Class I
Target:
INS
Specificity:
Human
Peptide:
ALWGPDPAAA
Conjugate:
APC
Class:
Class II
Target:
INS
Specificity:
Human
Peptide:
FVNQHLCGSHLVEAL
Conjugate:
PE
Class:
Class II
Target:
INS
Specificity:
Human
Peptide:
FVNQHLCGSHLVEAL
Conjugate:
PE
Class:
Class II
Target:
INS
Specificity:
Human
Peptide:
FVNQHLCGSHLVEAL
Conjugate:
PE
Class:
Class II
Target:
INS
Specificity:
Human
Peptide:
FVNQHLCGSHLVEAL
Conjugate:
PE
Class:
Class II
Target:
INS
Specificity:
Human
Peptide:
FVNQHLCGSHLVEAL
Conjugate:
PE
Species Reactivity:
Human
Epitope:
GSLQPLALEGSLQKRG
MHC:
HLA-DR4
Species Reactivity:
Human
Epitope:
GSLQPLALEGSLQKRG
MHC:
HLA-DR4
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