Recombinant Anti-INS (α chain x β chain) Biparatopic Antibody, Tandem scFv (Clone AE9D6 x Clone CB5)
CAT#: VS-0525-YC112
The Recombinant Anti-INS (α chain x β chain) Biparatopic Antibody, Tandem scFv (Clone AE9D6 x Clone CB5) is a biparatopic antibody (bpAb) engineered to bind two distinct epitopes of Insulin (INS). This bpAb employs a tandem scFv format, with the AE9D6 scFv (targeting the α chain loop) N-terminally fused to the CB5 scFv (recognizing the β chain loop).
Gene Expression
Normal Tissue
Figure 1 Pancreas
Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (EFO-21, U-2 OS, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS
❮
❯
Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Mouse
- Specificity
- Beef insulin
- Species Reactivity
- Bovine
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- AE9D6
- Clone 2
- CB5
- Epitope 1
- α chain loop
- Epitope 2
- β chain loop
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Insulin
Target
- Introduction
- After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
- Alternative Names
- Insulin; INS
- Gene ID
- 280829
- UniProt ID
- A5PJB2
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Related Diseases
Maturity Onset Diabetes of the Young
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "INS"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1554-VHH | Recombinant Anti-human INS VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1026 | Mouse Anti-INS Recombinant Antibody (clone YC182); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0182-YC-F(E) | Mouse Anti-INS Recombinant Antibody (clone 123); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1993-FY-F(E) | Human Anti-INS Recombinant Antibody (clone mAb48); Fab Fragment | ELISA | Human Fab, κ |
| HPAB-1994-FY-F(E) | Human Anti-INS Recombinant Antibody (clone mAb49); Fab Fragment | ELISA | Human Fab, κ |
| HPAB-1995-FY-F(E) | Human Anti-INS Recombinant Antibody (clone mAb13); Fab Fragment | ELISA | Human Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0152MZ | Recombinant Mouse Anti-Insulin/Proinsulin Antibody (clone E7C5) | ELISA, IHC-Fr | Mouse antibody |
| MRO-0841-CN | Mouse Anti-INS Recombinant Antibody (clone 5E1) | WB, ELISA, IHC | Mouse IgG1 |
| HPAB-1993-FY | Human Anti-INS Recombinant Antibody (clone mAb48) | ELISA | Human IgG3, κ |
| HPAB-1994-FY | Human Anti-INS Recombinant Antibody (clone mAb49) | ELISA | Human IgG1, κ |
| HPAB-1995-FY | Human Anti-INS Recombinant Antibody (clone mAb13) | ELISA | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1841 | Rabbit Anti-INS Recombinant Antibody (clone DS1841AB) | IHC-P, WB | Rabbit IgG |
| MOR-4627 | Rabbit Anti-INS Recombinant Antibody (clone TH140DS) | IF, ICC, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0182-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 123); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1993-FY-S(P) | Human Anti-INS Recombinant Antibody (clone mAb48); scFv Fragment | ELISA | Human scFv |
| HPAB-1994-FY-S(P) | Human Anti-INS Recombinant Antibody (clone mAb49); scFv Fragment | ELISA | Human scFv |
| HPAB-1995-FY-S(P) | Human Anti-INS Recombinant Antibody (clone mAb13); scFv Fragment | ELISA | Human scFv |
| PSBS-0026 | Anti-INS Recombinant Antibody (Clone 5ins16); scFv Fragment | ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF029 | DRB1*04:01/Human Proinsulin (GAGSLQPLALEGSLQKRG) MHC Monomer | MHC Multimer | |
| MHC-YF032 | DRB1*04:01/Human Proinsulin (GIVEQCCTSICSLYQ) MHC Monomer | MHC Multimer | |
| MHC-YF236 | A*02:01/Human Ins B. 10 (HLVEALYLV) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3566 | Anti-INS Immunohistochemistry Kit | IHC | |
| VS-0525-XY3567 | Anti-Mouse INS Immunohistochemistry Kit | IHC | |
| VS-0525-XY3568 | Anti-Rat INS Immunohistochemistry Kit | IHC |
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