Recombinant Anti-INS (α chain x β chain) Biparatopic Antibody, Tandem scFv (Clone AE9D6 x Clone CB5) (CAT#: VS-0525-YC112)

• Host Animal 1
• Mouse

• Host Animal 2
• Mouse

• Specificity
• Beef insulin

• Species Reactivity
• Bovine

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• AE9D6

• Clone 2
• CB5

• Epitope 1
• α chain loop

• Epitope 2
• β chain loop

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Insulin

• Introduction
• After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

• Alternative Names
• Insulin; INS

• Gene ID
• 280829

• UniProt ID
• A5PJB2

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