Recombinant Anti-INS Eliminating Antibody, pH-Sensitive (5ins16 var.)
CAT#: VS-0625-YC195
The anti-INS eliminating antibody is an engineered pH-sensitive antibody against human INS. INS is a insulin, crucial for glucose regulation and associated with various diabetes forms. The antibody has a novel INS-sweeping activity in vivo, which selectively eliminatesthe soluble INS from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 Pancreas
Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (EFO-21, U-2 OS, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human INS
- Species Reactivity
- Human
- Clone
- 5ins16 var.
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Related Diseases
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "INS"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1554-VHH | Recombinant Anti-human INS VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1026 | Mouse Anti-INS Recombinant Antibody (clone YC182); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0352JF-F(E) | Mouse Anti-INS Recombinant Antibody (clone CG7C7); Fab Fragment | ELISA, FuncS | Mouse Fab |
| FAMAB-0353JF-F(E) | Mouse Anti-INS Recombinant Antibody (clone AE9D6); Fab Fragment | ELISA, FuncS | Mouse Fab |
| FAMAB-0354JF-F(E) | Mouse Anti-INS Recombinant Antibody (clone CB5); Fab Fragment | ELISA, FuncS | Mouse Fab |
| FAMAB-0355JF-F(E) | Mouse Anti-INS Recombinant Antibody (clone CA4); Fab Fragment | ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0152MZ | Recombinant Mouse Anti-Insulin/Proinsulin Antibody (clone E7C5) | ELISA, IHC-Fr | Mouse antibody |
| FAMAB-0352JF | Mouse Anti-INS Recombinant Antibody (clone CG7C7) | ELISA, FuncS | Mouse IgG1 |
| MOB-0058F | Mouse Anti-INS Recombinant Antibody (MOB-0058F) | IHC-P, IF | Mouse IgG |
| MOB-0059F | Mouse Anti-INS Recombinant Antibody (MOB-0059F) | IHC-P, IF | Mouse IgG |
| ZG-0811F | Mouse Anti-INS Recombinant Antibody (clone E2E3) | WB, ELISA, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1841 | Rabbit Anti-INS Recombinant Antibody (clone DS1841AB) | IHC-P, WB | Rabbit IgG |
| MOR-4627 | Rabbit Anti-INS Recombinant Antibody (clone TH140DS) | IF, ICC, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF029 | DRB1*04:01/Human Proinsulin (GAGSLQPLALEGSLQKRG) MHC Monomer | MHC Multimer | |
| MHC-YF032 | DRB1*04:01/Human Proinsulin (GIVEQCCTSICSLYQ) MHC Monomer | MHC Multimer | |
| MHC-YF236 | A*02:01/Human Ins B. 10 (HLVEALYLV) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0352JF-S(P) | Mouse Anti-INS Recombinant Antibody (clone CG7C7); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0353JF-S(P) | Mouse Anti-INS Recombinant Antibody (clone AE9D6); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0354JF-S(P) | Mouse Anti-INS Recombinant Antibody (clone CB5); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0355JF-S(P) | Mouse Anti-INS Recombinant Antibody (clone CA4); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0356JF-S(P) | Mouse Anti-INS Recombinant Antibody (clone BE3F9); scFv Fragment | ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3566 | Anti-INS Immunohistochemistry Kit | IHC | |
| VS-0525-XY3567 | Anti-Mouse INS Immunohistochemistry Kit | IHC | |
| VS-0525-XY3568 | Anti-Rat INS Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC112 | Recombinant Anti-INS (α chain x β chain) Biparatopic Antibody, Tandem scFv (Clone AE9D6 x Clone CB5) | ELISA | Tandem scFv |
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