DRB1*04:01/Human Proinsulin (GAGSLQPLALEGSLQKRG) MHC Monomer
CAT#: MHC-YF029
This product is a MHC monomer of biotinylated peptide/MHC complex composed Proinsulin-derived peptide of GAGSLQPLALEGSLQKRG sequence covering 73-90 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Pancreas
Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (EFO-21, U-2 OS, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS
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Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Proinsulin
- Antigen Species
- Human
- Peptide
- GAGSLQPLALEGSLQKRG
- Range
- 73-90
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
- Alternative Names
- IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
- Gene ID
- 3630
- UniProt ID
- P01308
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Highly Recommended for Immunological Research
We have used several MHC monomers, but this specific one stands out due to its clear applicability in understanding immune responses to proinsulin.
Streamlined and Efficient
From product ordering to implementation in research workflows, everything about this product has been efficient. The clear protocols and reliable data outputs have made this MHC monomer a preferred choice in our lab's studies on infectious disease and autoimmune interactions.
Q&As
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How is the peptide component of the MHC monomer derived?
A: The peptide component, GAGSLQPLALEGSLQKRG, is derived from the proinsulin protein. This sequence is integral for binding with T cells, aiding in the study of autoimmune responses and antigen processing.
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What conjugation does this MHC monomer have, and why is it important?
A: This MHC monomer is conjugated with biotin, which is crucial for its utility in various labeling and detection assays including flow cytometry and immunoassays.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "INS"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1554-VHH | Recombinant Anti-human INS VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1026 | Mouse Anti-INS Recombinant Antibody (clone YC182); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0352JF-F(E) | Mouse Anti-INS Recombinant Antibody (clone CG7C7); Fab Fragment | ELISA, FuncS | Mouse Fab |
| FAMAB-0353JF-F(E) | Mouse Anti-INS Recombinant Antibody (clone AE9D6); Fab Fragment | ELISA, FuncS | Mouse Fab |
| FAMAB-0354JF-F(E) | Mouse Anti-INS Recombinant Antibody (clone CB5); Fab Fragment | ELISA, FuncS | Mouse Fab |
| FAMAB-0355JF-F(E) | Mouse Anti-INS Recombinant Antibody (clone CA4); Fab Fragment | ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0152MZ | Recombinant Mouse Anti-Insulin/Proinsulin Antibody (clone E7C5) | ELISA, IHC-Fr | Mouse antibody |
| PABS-0026 | Anti-INS Recombinant Antibody (Clone 5ins16) | ELISA, FuncS | IgG |
| VS3-CJ254 | Mouse Anti-INS Recombinant Antibody (clone ABT-INS) | IHC-P | Mouse IgG2b, κ |
| VS3-CJ255 | Mouse Anti-INS Recombinant Antibody (clone PT2015) | IHC-P | Mouse IgG2b, κ |
| VS3-CJ256 | Mouse Anti-INS Recombinant Antibody (VS3-CJ256) | IHC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1841 | Rabbit Anti-INS Recombinant Antibody (clone DS1841AB) | IHC-P, WB | Rabbit IgG |
| MOR-4627 | Rabbit Anti-INS Recombinant Antibody (clone TH140DS) | IF, ICC, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF032 | DRB1*04:01/Human Proinsulin (GIVEQCCTSICSLYQ) MHC Monomer | MHC Multimer | |
| MHC-YF236 | A*02:01/Human Ins B. 10 (HLVEALYLV) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0352JF-S(P) | Mouse Anti-INS Recombinant Antibody (clone CG7C7); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0353JF-S(P) | Mouse Anti-INS Recombinant Antibody (clone AE9D6); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0354JF-S(P) | Mouse Anti-INS Recombinant Antibody (clone CB5); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0355JF-S(P) | Mouse Anti-INS Recombinant Antibody (clone CA4); scFv Fragment | ELISA, FuncS | Mouse scFv |
| PSBS-0026 | Anti-INS Recombinant Antibody (Clone 5ins16); scFv Fragment | ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3566 | Anti-INS Immunohistochemistry Kit | IHC | |
| VS-0525-XY3567 | Anti-Mouse INS Immunohistochemistry Kit | IHC | |
| VS-0525-XY3568 | Anti-Rat INS Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC112 | Recombinant Anti-INS (α chain x β chain) Biparatopic Antibody, Tandem scFv (Clone AE9D6 x Clone CB5) | ELISA | Tandem scFv |
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