DRB1*04:01/Human Proinsulin (GAGSLQPLALEGSLQKRG) MHC Monomer (CAT#: MHC-YF029)
This product is a MHC monomer of biotinylated peptide/MHC complex composed Proinsulin-derived peptide of GAGSLQPLALEGSLQKRG sequence covering 73-90 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Pancreas
(Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg
(Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg
Figure 2 RNA cell line category: Group enriched (EFO-21, U-2 OS, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Proinsulin
- Antigen Species
- Human
- Peptide
- GAGSLQPLALEGSLQKRG
- Range
- 73-90
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
- Alternative Names
- IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
- Gene ID
- 3630
- UniProt ID
- P01308
Related Resources
Maturity Onset Diabetes of the Young
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1554-VHH | Recombinant Anti-human INS VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
Customer Reviews and Q&As
Customer Review
Q&As
Highly Recommended for Immunological Research
We have used several MHC monomers, but this specific one stands out due to its clear applicability in understanding immune responses to proinsulin.
Streamlined and Efficient
From product ordering to implementation in research workflows, everything about this product has been efficient. The clear protocols and reliable data outputs have made this MHC monomer a preferred choice in our lab's studies on infectious disease and autoimmune interactions.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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