PE-DQB1*03:02/Human GAD2 (CDGERPTLAFLQDVM) MHC Tetramer
CAT#: MHC-LC3225
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human GAD2 of peptide CDGERPTLAFLQDVM covering 101-115 and DQB1*03:02 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78177/163309_B_9_5.jpg
Normal Tissue
Figure 2 Pancreas
Pancreatic endocrine cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78177/163309_A_3_3.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (SCLC-21H)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136750-GAD2
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Specifications
- Allele
- DQB1*03:02
- Class
- Class II
- MHC Species
- Human
- Antigen
- GAD2
- Antigen Species
- Human
- Peptide
- CDGERPTLAFLQDVM
- Range
- 101-115
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
- Alternative Names
- GAD2; Glutamate decarboxylase 2; GAD65
- Gene ID
- 2572
- UniProt ID
- Q05329
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Related Diseases
Maturity Onset Diabetes of the Young
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Datasheet
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