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PE-DRB*01:01/Human CD74 (KMRMATPLLMQALPM) MHC Tetramer (CAT#: MHC-LC1598)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of CD74-derived peptide of KMRMATPLLMQALPM covering 106-120 and DRB*01:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.

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  • Gene Expression
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/if_selected.jpg
Figure 2 IHC staining of human spleen
Figure 2 IHC staining of human spleen
(Immunohistochemical staining of human spleen shows strong granular cytoplasmic positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10592/ihc_selected.jpg
Figure 3 IHC staining of human tonsil
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in germinal center cells and non-germinal center cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79994/170659_A_6_8_selected.jpg
Figure 4 IF staining of human cell line U-251 MG
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/203_F11_1_blue_red_green.jpg
Normal Tissue
Figure 5 Colon
Figure 5 Colon
(Mucosal lymphoid cells
Staining:High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_7_3.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_8_5.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_8_8.jpg
Figure 8 Tonsil
Figure 8 Tonsil
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_6_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, HDLM-2, REH, RPMI-8226, U-266/70, U-698)
Figure 9 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, HDLM-2, REH, RPMI-8226, U-266/70, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000019582-CD74

Specifications

  • Allele
  • DRB*01:01
  • Class
  • Class II
  • MHC Species
  • Human
  • Antigen
  • CD74
  • Antigen Species
  • Human
  • Peptide
  • KMRMATPLLMQALPM
  • Range
  • 106-120
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Alternative Names
  • CD74; CD74 molecule; II; DHLAG; HLADG; Ia-GAMMA

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NAB-466-VHH Recombinant Anti-Human CD74 VHH Single Domain Antibody FUNC, FA, IP, ChiP Llama VHH
TAB-0004CL-VHH Anti-Human CD74 VHH Single Domain Antibody (TAB-0004CL-VHH) ELISA, FC, Internalization, Inhib, FuncS VHH
TAB-0005CL-VHH Anti-Human CD74 VHH Single Domain Antibody (TAB-0005CL-VHH) ELISA, FC, Internalization, Inhib, FuncS VHH
TAB-0006CL-VHH Anti-Human CD74 VHH Single Domain Antibody (TAB-0006CL-VHH) ELISA, FC, Internalization, Inhib, FuncS VHH
TAB-0007CL-VHH Anti-Human CD74 VHH Single Domain Antibody (TAB-0007CL-VHH) ELISA, FC, Internalization, Inhib, FuncS VHH

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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