Does this antibody react with species other than human?

Yes, this Recombinant Human Antibody recognizes CD74 and reacts with both Human and Monkey samples. It is an IgG antibody purified by affinity chromatography and is suitable for Flow Cytometry.

What is the purity of this CD74 antibody?

The purity of this antibody is greater than 95% as determined by SDS-PAGE. It is a high-quality reagent designed to recognize the CD74 molecule, also known as the invariant chain of the MHC class II antigen-associated complex.

Human Anti-CD74 Recombinant Antibody (HPAB-0388-FY)

CAT#: HPAB-0388-FY

This product is a recombinant human antibody that recognizes CD74. The antibody was purified by affinity chromatography. It can be used for FC and other applications.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/if_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human spleen

Immunohistochemical staining of human spleen shows strong granular cytoplasmic positivity.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10592/ihc_selected.jpg

Subcellular Location and Protein Expression Figure 3 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in germinal center cells and non-germinal center cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79994/170659_A_6_8_selected.jpg

Subcellular Location and Protein Expression Figure 4 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/203_F11_1_blue_red_green.jpg

Normal Tissue Figure 5 Colon

Mucosal lymphoid cells
Staining:High
Intensity: Strong
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_7_3.jpg

Normal Tissue Figure 6 Kidney

Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_8_5.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_8_8.jpg

Normal Tissue Figure 8 Tonsil

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_6_8.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, HDLM-2, REH, RPMI-8226, U-266/70, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000019582-CD74

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Specifications

Host Species
Human

Type
Human IgG

Specificity
Human CD74

Species Reactivity
Human, Monkey

Applications
FC

Related Disease
Cancers, Autoimmune diseases, Infection, Inflammation

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
CD74 Molecule; CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex; Class II Antigen-Associated); CD74 Molecule; Major Histocompatibility Complex; Class II Invariant Chain; HLA-DR Antigens-Associated Invariant Chain; Gamma Chain Of Class II Antigens; Ia-Associated Invariant Chain; MHC HLA-DR Gamma Chain; HLA-DR-Gamma; DHLAG;

Gene ID
972

UniProt ID
P04233

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Breast cancer biomarkers at key points during disease progression

Excellent Flow Cytometry

We used this recombinant human antibody for flow cytometry analysis of CD74 expression. It gave distinct peaks and helped us analyze the invariant chain on our cells. The affinity purification ensures a high-quality reagent.

Reactive With Monkey

It is useful that this antibody reacts with both human and monkey CD74. We utilized it in our comparative studies and the binding was consistent. Storage and handling were straightforward with standard buffers.

Q&As

Does this antibody react with species other than human?

A: Yes, this Recombinant Human Antibody recognizes CD74 and reacts with both Human and Monkey samples. It is an IgG antibody purified by affinity chromatography and is suitable for Flow Cytometry.
What is the purity of this CD74 antibody?

A: The purity of this antibody is greater than 95% as determined by SDS-PAGE. It is a high-quality reagent designed to recognize the CD74 molecule, also known as the invariant chain of the MHC class II antigen-associated complex.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0388-FY.pdf

MSDS

MSDS - HPAB-0388-FY.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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