Anti-CD79b (Polatuzumab)-vc-MMAE ADC
CAT#: ADC-087LCT
This ADC product is composed of an anti-CD79b antibody (Polatuzumab) conjuagated via a vc linker to MMAE (Polatuzumab-vc-MMAE). It has demonstrated a response in NHL and DLBCL treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/1889_C4_3_selected.jpg
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Specifications
- Antibody Overview
- Humanized IgG1 (Anti-CD79b)
- Clone
- Polatuzumab
- Antibody Isotype
- IgG1
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);
- Gene ID
- 974
- UniProt ID
- P40259
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Related Signaling Pathways
BCR Signaling Pathway
Downloadable Resources
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Datasheet
MSDS
COA
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- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-897 | Humanized Anti-CD79B Recombinant Antibody (TAB-897) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Humanized (from mouse) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0581 | Hi-Affi™ Rabbit Anti-CD79B Recombinant Antibody (clone DS581AB) | WB, IHC, ICC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1918 | PE-A*02:01/Human CD79B (LLSAEPVPA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0058YC | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16) | FuncS | Hamster IgG |
| HPAB-618-FY | Human Anti-CD79B Recombinant Antibody (HPAB-618-FY) | FC, ELISA | Human IgG |
| HPAB-619-FY | Human Anti-CD79B Recombinant Antibody (HPAB-619-FY) | FC, ELISA | Humanized IgG |
| HPAB-J0055-YC | Human Anti-CD79B Recombinant Antibody (HPAB-J0055-YC) | ELISA, FC, Inhib, FuncS | Humanized IgG1 |
| HPAB-J0056-YC | Human Anti-CD79B Recombinant Antibody (HPAB-J0056-YC) | ELISA, FC, Inhib, FuncS | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0058-YC-S(P) | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16); scFv Fragment | FuncS | Hamster scFv |
| HPAB-618-FY-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-618-FY-S(P)) | FC, ELISA | Humanized scFv |
| HPAB-619-FY-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-619-FY-S(P)) | FC, ELISA | Humanized scFv |
| HPAB-1491-FY-F(E) | Human Anti-CD79B Recombinant Antibody Fab Fragment (HPAB-1491-FY-F(E)) | ELISA, WB | Human Fab |
| HPAB-1938-FY-S(P) | Mouse Anti-CD79B Recombinant Antibody scFv Fragment (HPAB-1938-FY-S(P)) | ELISA, FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0364LY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-0364LY-F(E)) | Inhib, ELISA | Human Fab |
| HPAB-N0044-YC-F(E) | Human Anti-CD79b Recombinant Antibody; Fab Fragment (HPAB-N0044-YC-F(E)) | FuncS | Humanized Fab |
| HPAB-1059-FY-S(P) | Mouse Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-1059-FY-S(P)) | FC | Mouse scFv |
| HPAB-1938-FY-F(E) | Mouse Anti-CD79B Recombinant Antibody Fab Fragment (HPAB-1938-FY-F(E)) | ELISA, FC, FuncS | Mouse Fab, κ |
| HPAB-1939-FY-F(E) | Human Anti-CD79B Recombinant Antibody Fab Fragment (HPAB-1939-FY-F(E)) | ELISA, FC, FuncS | Humanized Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-897 | Afuco™ Anti-CD79B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-897) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY72 | CytoStream™ Mouse Anti-CD79B Recombinant Antibody (clone CB3-1) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY74 | Human Anti-CD79B (clone P2C2) scFv-Fc Chimera | IA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC74 | Recombinant Anti-CD79B Vesicular Antibody, EV Displayed (VS-0425-YC74) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1222 | Anti-Mouse CD79B Immunohistochemistry Kit | IHC |
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