Anti-PSMA-mc-MMAF ADC
CAT#: ADC-192CL
This ADC product is composed of an anti-PSMA antibody conjugated via mc linker to MMAF(anti-PSMA-mc-MMAF). It has demonstrated a response in PSMA-mediated disease treatment by a MOA (Mechanism of Action) as microtubule inhibitor.
Gene Expression
Normal Tissue
Figure 1 Kidney
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
Normal Tissue
Figure 2 Prostate
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
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Specifications
- Antibody Overview
- Anti-PSMA Antibody,
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
- Alternative Names
- FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I;
- Gene ID
- 2346
- UniProt ID
- Q04609
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PSMA Expression Analysis Tool
This anti-PSMA ADC has been a reliable reagent for our studies on glutamate carboxypeptidase II expression. The antibody recognizes the target on the cell surface, and the conjugation to MMAF via the mc linker allows us to study the effects of targeted microtubule inhibition in cells overexpressing this glycoprotein.
Stable Maleimidocaproyl Linker
We chose this product for its noncleavable maleimidocaproyl (mc) linker. It is crucial for our research that the linker remains stable in plasma-like conditions. The release of MMAF upon lysosomal degradation of the antibody was confirmed in our intracellular tracking experiments, validating the design for our needs.
Q&As
-
What type of linker is used in this Anti-PSMA ADC?
A: This ADC uses a maleimidocaproyl (mc) linker. This is classified as a noncleavable linker. The payload release depends on the degradation of the antibody component within the lysosome after the complex has been internalized by the target cell.
-
How does this product inhibit cell division?
A: The product contains MMAF (Monomethyl auristatin F), which is a tubulin inhibitor. MMAF acts as a microtubule inhibitor by binding to tubulin and preventing polymerization. This causes the cell to arrest in metaphase, thereby stopping cell division.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
MSDS
COA
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