Anti-PSMA-mc-MMAF ADC (CAT#: ADC-192CL)

This ADC product is composed of an anti-PSMA antibody conjugated via mc linker to MMAF(anti-PSMA-mc-MMAF). It has demonstrated a response in PSMA-mediated disease treatment by a MOA (Mechanism of Action) as microtubule inhibitor.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-PSMA Antibody,
  • Linker
  • Mc (maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linkers
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • MMAF (Monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
  • Alternative Names
  • FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I;

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G029E Anti-FOLH1 immunotoxin D7 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G029D Anti-FOLH1 immunotoxin D7 (scFv)-DT Cytotoxicity assay, Function study

Mouse Antibody

CAT Product Name Application Type
TAB-274CT Mouse Anti-FOLH1 Recombinant Antibody (TAB-274CT) FC, IA, IHC, Inhib, IB, IF, WB, ELISA Mouse IgG2a
TAB-275CT Mouse Anti-FOLH1 Recombinant Antibody (TAB-275CT) ICC, FC, Block, IB, IF, IHC, Inhib, WB, ELISA Mouse IgG1
TAB-276CT Mouse Anti-FOLH1 Recombinant Antibody (TAB-276CT) IB, FC, IF, Inhib, WB, ELISA, IHC Mouse IgG2b
TAB-278CT Anti-Human PSMA Recombinant Antibody (L-186) WB, ELISA, IP, IF
TAB-279CT Mouse Anti-FOLH1 Recombinant Antibody (TAB-279CT) FC, WB, ICC, SPR, RIA, IF, ELISA, IHC Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1332 Hi-Affi™ Rabbit Anti-FOLH1 Recombinant Antibody (clone DS1332AB) IHC-P Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-018 Afuco™ Anti-FOLH1 ADCC Recombinant Antibody (Capromab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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