AbPlus™ Anti-ADAM17 Magnetic Beads (VS-0724-YC601)
CAT#: VS-0724-YC601
The AbPlus Anti-ADAM17 Magnetic Beads (VS-0724-YC601) is an innovative affinity resin which is bound with anti-ADAM17 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of ADAM17 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/51575/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows membranous and cytoplasmic positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_7_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_4_6.jpg
Normal Tissue
Figure 9 Placenta
Trophoblastic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_2_7.jpg
Normal Tissue
Figure 10 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_9_8.jpg
RNA Expression
Figure 11 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000151694-ADAM17
❮
❯
Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-ADAM17 specific antibody
- Target
- ADAM17
- Immunogen
- Synthetic peptide corresponding to the C-terminus of the human CD156b.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
- Alternative Names
- ADAM Metallopeptidase Domain 17; Tumor Necrosis Factor, Alpha, Converting Enzyme; Snake Venom-Like Protease; TNF-Alpha Convertase; EC 3.4.24.86; TACE; CSVP; Disintegrin And Metalloproteinase Domain-Containing Protein 17; ADAM Metallopeptidase Domain 18;
- Gene ID
- 6868
- UniProt ID
- P78536
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-38 | Recombinant Anti-human ADAM17 Antibody | ELISA, WB, FC, FuncS | IgG |
| MOB-0437MZ | Mouse Anti-ADAM17 Recombinant Antibody (clone 1F6) | FC, IF, IHC-P, WB | Mouse IgG |
| MRO-0030-CN | Rabbit Anti-ADAM17 Recombinant Antibody (clone JM10-35) | WB, IF, IP, FC | Rabbit IgG |
| ZG-0529J | Rabbit Anti-ADAM17 Recombinant Antibody (clone 5A1) | ELISA, IF | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-38-F(E) | Recombinant Anti-human ADAM17 Antibody Fab Fragment | ELISA, WB, FuncS | Fab |
| MHH-38-F(E) | Recombinant Human Anti-human ADAM17 Antibody Fab Fragment | ELISA, WB, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-38-S(P) | Recombinant Anti-human ADAM17 Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| MHH-38-S(P) | Recombinant Human Anti-human ADAM17 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0444CL | Anti-Human ADAM17 Recombinant Antibody (ml022C3) | ELISA, Inhib, FuncS | |
| TAB-0444CL-S(P) | Anti-Human ADAM17 Recombinant Antibody scFv Fragment (ml022C3) | ELISA, Inhib, FuncS | |
| TAB-0444CL-F(E) | Anti-Human ADAM17 Recombinant Antibody Fab Fragment (ml022C3) | ELISA, Inhib, FuncS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0445CL | Anti-Human ADAM17 Recombinant Antibody (cl022C3) | ELISA, Inhib, FuncS | Chimeric (mouse/human) |
| TAB-0445CL-S(P) | Anti-Human ADAM17 Recombinant Antibody scFv Fragment (cl022C3) | ELISA, Inhib, FuncS | Chimeric (mouse/human) |
| TAB-0445CL-F(E) | Anti-Human ADAM17 Recombinant Antibody Fab Fragment (cl022C3) | ELISA, Inhib, FuncS | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0446CL | Anti-Human ADAM17 Recombinant Antibody (hzl022C3) | ELISA, Inhib, FuncS | Humanized Antibody |
| TAB-0446CL-S(P) | Anti-Human ADAM17 Recombinant Antibody scFv Fragment (hzl022C3) | ELISA, Inhib, FuncS | Humanized Antibody |
| TAB-0446CL-F(E) | Anti-Human ADAM17 Recombinant Antibody Fab Fragment (hzl022C3) | ELISA, Inhib, FuncS | Humanized Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0447CL | Anti-Human ADAM17 Recombinant Antibody (hl022C3) | ELISA, Inhib, FuncS | Human antibody |
| TAB-0447CL-S(P) | Anti-Human ADAM17 Recombinant Antibody scFv Fragment (hl022C3) | ELISA, Inhib, FuncS | Human antibody |
| TAB-0447CL-F(E) | Anti-Human ADAM17 Recombinant Antibody Fab Fragment (hl022C3) | ELISA, Inhib, FuncS | Human antibody |
| TAB-0669CLV | Anti-Human ADAM17 Recombinant Antibody (D1(A12)) | ELISA, PK, Inhib, IHC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0070 | Hi-Affi™ Rabbit Anti-ADAM17 Recombinant Antibody (clone DS70AB) | WB, IF, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0393 | PE-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer | FCM, IHC | |
| MHC-CN0394 | APC-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer | FCM, IHC | |
| MHC-CN0395 | FITC-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer | FCM, IHC | |
| MHC-CN0396 | A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY41 | Anti-ADAM17 Immunohistochemistry Kit | IHC | |
| VS-0525-XY149 | Anti-Human ADAM17 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC313 | Recombinant Anti-ADAM17 Vesicular Antibody, EV Displayed (VS-0425-YC313) | ELISA, FC, Cell-uptake |
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