FITC-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer

CAT#: MHC-CN0395

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 IF staining of human cell line U-251 MG Figure 3 IHC staining of human small intestine Figure 4 Cerebral cortex Figure 5 Colon Figure 6 Liver Figure 7 Kidney Figure 8 Testis Figure 9 Placenta Figure 10 Lymph node Figure 11 RNA cell line category: Low cell line specificity

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • ADAM17
  • Antigen Species
  • Human
  • Peptide
  • YLIELIDRV
  • Conjugate
  • FITC

Target

  • Antigen Introduction
  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
  • Alternative Names
  • CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1
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Protocol & Troubleshooting

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