Mouse Anti-ALK/p80 Recombinant Antibody (VS3-FY2624) (CAT#: VS3-FY2624)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• ALK receptor tyrosine kinase of human

• Species Reactivity
• Human

• Applications
• WB, FC, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 176.4 kDa.

• Related Disease
• Neuroblastoma 3 and Neuroblastoma

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• ALK Receptor Tyrosine Kinase; Anaplastic Lymphoma Receptor Tyrosine Kinase; CD246 Antigen; EC 2.7.10.1; Anaplastic Lymphoma Kinase (Ki-1); Mutant Anaplastic Lymphoma Kinase

• Gene ID
• 238

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
  In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation.
  Phosphorylation at Tyr-1507 is critical for SHC1 association.
  N-glycosylated.
  Glycosylation at Asn169, Asn244, Asn285, Asn324, Asn411, Asn424, Asn445, Asn563, Asn571, Asn627, Asn709, Asn808, Asn863, Asn864, Asn886, and Asn986
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 17 sites, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_054197220.1; NP_001340694.1; NP_004295.2

• Function
• Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, 11387242, 16317043, 17274988, 30061385, 34646012, 34819673).
  Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity).
  Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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