Anti-APOE (clone 2E8) Recombinant Antibody Coupled Liposome (VS-1024-FY13)
CAT#: VS-1024-FY13
This innovative anti-ApoE conjugated liposome, designed as an immunoliposome (IL), has shown promise in selectively binding to activated human coronary artery endothelial cells (HCAEC). By leveraging this targeting mechanism, the liposome could enhance the imaging capabilities of computed tomography, facilitating the early detection of atherosclerotic plaques before they lead to significant cardiovascular events. The potential application of this imaging agent represents a significant advancement in cardiovascular diagnostics, offering a non-invasive method to assess and monitor arterial health.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/1270_D3_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_B_9_5.jpg
Normal Tissue
Figure 3 High expression in liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_7_4.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, CACO-2, Hep G2, HSkMC, SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130203-APOE
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More Infomation
Specifications
- Potential Clinical Applications
- Early detection of atherosclerotic plaques
Product Composition
- Clone
- 2E8
- Antibody Type
- IgG1, kappa
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant monoclonal antibody that was derived from mice that specifically targets apolipoprotein E (APOE). It is designed to recognize the low-density lipoprotein (LDL) receptor-binding region of apoE, facilitating the study of the interaction between apoE and the LDL receptor by binding to specific epitopes within this critical region.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- APOE
- Introduction
- The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
- Alternative Names
- Apolipoprotein E; APO-E; Alzheimer Disease 2 (APOE*E4-Associated, Late Onset); Apolipoprotein E3; LDLCQ5; ApoE4; LPG; AD2
- Full Name
- Apolipoprotein E
- Gene ID
- 348
- UniProt ID
- P02649
- Sequence Similarities
- Belongs to the apolipoprotein A1/A4/E family.
- Post Translation Modifications
- APOE exists as multiple glycosylated and sialylated glycoforms within cells and in plasma (PubMed:29516132).
The extent of glycosylation and sialylation are tissue and context specific (PubMed:29516132).
Plasma APOE undergoes desialylation and is less glycosylated and sialylated than the cellular form.
- Protein Refseq
- NP_000032.1; NP_001289617.1; NP_001289618.1; NP_001289619.1; NP_001289620.1
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Datasheet
MSDS
COA
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See other products for "Clone 2E8"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1659z | Mouse Anti-APOE Recombinant Antibody (clone 41D9) | WB, ELISA, FC, ICC, IF, IHC, IP | Mouse IgG1, κ |
| HPAB-0115CQ | Mouse Anti-APOE Recombinant Antibody (clone 2E8) | ELISA, Block, SPR | Mouse IgG1, κ |
| MRO-0113-CN | Rabbit Anti-APOE Recombinant Antibody (clone CBACN-038) | WB, IF, IHC, IP | Rabbit IgG |
| MRO-1656-CN | Rabbit Anti-APOE Polyclonal Antibody (MRO-1656-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS7-HM120 | Mouse Anti-APOE Recombinant Antibody (clone CBL044HM) | WB, IHC-p, IF, FCM, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-072 | Recombinant Anti-human APOE VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0976CLV | Human Anti-APOE Recombinant Antibody (TAB-0976CLV) | ELISA, IP | Human IgG |
| TAB-0976CLV-F(E) | Human Anti-APOE Recombinant Antibody; Fab Fragment (TAB-0976CLV-F(E)) | ELISA, IP | Human Fab |
| TAB-0976CLV-S(P) | Human Anti-APOE Recombinant Antibody; scFv Fragment (TAB-0976CLV-S(P)) | ELISA, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-024CQ | Recombinant Mouse Anti-APOE Antibody | ELISA, BL | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0215 | Hi-Affi™ Rabbit Anti-APOE Recombinant Antibody (clone DS215AB) | FC, IHC-P, IP, WB | Rabbit IgG |
| MOR-4534 | Hi-Affi™ Rabbit Anti-APOE Recombinant Antibody (clone TH42DS) | WB, IF, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0315-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0315-YC-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-N0316-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0316-YC-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-N0317-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0317-YC-S(P)) | IP, ELISA, WB | Mouse scFv |
| HPAB-N0318-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0318-YC-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0115CQ-S(P) | Mouse Anti-APOE Recombinant Antibody (clone 2E8); scFv Fragment | ELISA, Block | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0315-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0315-YC-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-N0316-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0316-YC-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-N0317-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0317-YC-F(E)) | IP, ELISA, WB | Mouse Fab |
| HPAB-N0318-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0318-YC-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0115CQ-F(E) | Mouse Anti-APOE Recombinant Antibody (clone 2E8); Fab Fragment | ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY16 | AbPlus™ Anti-APOE Magnetic Beads (VS-0424-XY16) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY51 | Mouse Anti-ApoE (clone W25-2E8) scFv-Fc Chimera | ELISA, Block, SPR | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY462 | Anti-APOE Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC24 | Recombinant Anti-APOE Eliminating Antibody, pH-Sensitive (2E8 var.) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
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