Anti-APOE (clone 2E8) Recombinant Antibody Coupled Liposome (VS-1024-FY13) (CAT#: VS-1024-FY13)
This innovative anti-ApoE conjugated liposome, designed as an immunoliposome (IL), has shown promise in selectively binding to activated human coronary artery endothelial cells (HCAEC). By leveraging this targeting mechanism, the liposome could enhance the imaging capabilities of computed tomography, facilitating the early detection of atherosclerotic plaques before they lead to significant cardiovascular events. The potential application of this imaging agent represents a significant advancement in cardiovascular diagnostics, offering a non-invasive method to assess and monitor arterial health.
More Infomation
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/1270_D3_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/1270_D3_2_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_B_9_5.jpg
Figure 3 High expression in liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_7_4.jpg
Figure 4 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_6_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, CACO-2, Hep G2, HSkMC, SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130203-APOE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130203-APOE
Specifications
- Potential Clinical Applications
- Early detection of atherosclerotic plaques
Product Composition
- Clone
- 2E8
- Antibody Type
- IgG1, kappa
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant monoclonal antibody that was derived from mice that specifically targets apolipoprotein E (APOE). It is designed to recognize the low-density lipoprotein (LDL) receptor-binding region of apoE, facilitating the study of the interaction between apoE and the LDL receptor by binding to specific epitopes within this critical region.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- APOE
- Introduction
- The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
- Alternative Names
- Apolipoprotein E; APO-E; Alzheimer Disease 2 (APOE*E4-Associated, Late Onset); Apolipoprotein E3; LDLCQ5; ApoE4; LPG; AD2
- Full Name
- Apolipoprotein E
- Gene ID
- 348
- UniProt ID
- P02649
- Sequence Similarities
- Belongs to the apolipoprotein A1/A4/E family.
- Post Translation Modifications
- APOE exists as multiple glycosylated and sialylated glycoforms within cells and in plasma (PubMed:29516132).
The extent of glycosylation and sialylation are tissue and context specific (PubMed:29516132).
Plasma APOE undergoes desialylation and is less glycosylated and sialylated than the cellular form.
- Protein Refseq
- NP_000032.1; NP_001289617.1; NP_001289618.1; NP_001289619.1; NP_001289620.1
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-072 | Recombinant Anti-human APOE VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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