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For Research Use Only. Not For Clinical Use.
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins
Secreted
Cell type enhanced (Muller glia cells, Hepatocytes, Proximal tubular cells, Theca cells, Hofbauer cells, Peritubular cells)
Not detected in immune cells
Cell line enhanced (ASC diff, CACO-2, Hep G2, HSkMC, SK-MEL-30)
Homotetramer (PubMed:8340399). May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs (PubMed:14754908). May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear (PubMed:8367470, PubMed:23620513). May interact with MAPT (PubMed:7972031). May interact with MAP2 (PubMed:7891887). In the cerebrospinal fluid, interacts with secreted SORL1 (PubMed:30448281). (Microbial infection) Interacts with hepatitis C virus (HCV) envelope glycoprotein E2; this interaction is required for HCV infectivity and production.
Heparin-binding