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APOE

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For Research Use Only. Not For Clinical Use.


Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues
Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Muller glia cells, Hepatocytes, Proximal tubular cells, Theca cells, Hofbauer cells, Peritubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff, CACO-2, Hep G2, HSkMC, SK-MEL-30)

Interaction

Homotetramer (PubMed:8340399). May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs (PubMed:14754908). May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear (PubMed:8367470, PubMed:23620513). May interact with MAPT (PubMed:7972031). May interact with MAP2 (PubMed:7891887). In the cerebrospinal fluid, interacts with secreted SORL1 (PubMed:30448281). (Microbial infection) Interacts with hepatitis C virus (HCV) envelope glycoprotein E2; this interaction is required for HCV infectivity and production.

Molecular function

Heparin-binding

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