Mouse Anti-ApoE (clone W25-2E8) scFv-Fc Chimera (CAT#: VS-0125-FY51)
anti-ApoE scFv-Fc is a recombinant single-chain antibody-Fc fusion variant targeting human apolipoprotein E (ApoE). This molecule typically consists of a small single-chain antibody (scFv) linked to the human IgG Fc portion to enhance stability and efficacy. anti-ApoE scFv-Fc is a promising antibody molecule for the study and potential treatment of diseases such as Alzheimer's disease. It combines the advantages of a small size and high affinity of scFv with the functional capabilities of the Fc region, making it a multifunctional biopharmaceutical candidate. Future research may further explore its specific roles and mechanisms in therapy.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/1270_D3_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/1270_D3_2_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_B_9_5.jpg
Figure 3 High expression in liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_7_4.jpg
Figure 4 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_6_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, CACO-2, Hep G2, HSkMC, SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130203-APOE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130203-APOE
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- W25-2E8
- Applications
- ELISA, Blocking, Surface Plasmon Resonance
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ApoE is closely related to the pathogenesis of neurodegenerative diseases such as Alzheimer's disease; therefore, antibodies targeting ApoE may have potential therapeutic significance.
Target
- Alternative Names
- Apolipoprotein E; APO-E; Alzheimer Disease 2 (APOE*E4-Associated, Late Onset); Apolipoprotein E3; LDLCQ5; ApoE4; LPG; AD2
- Gene ID
- 348
- UniProt ID
- P02649
- Sequence Similarities
- Belongs to the apolipoprotein A1/A4/E family.
- Post Translation Modifications
- APOE exists as multiple glycosylated and sialylated glycoforms within cells and in plasma.
The extent of glycosylation and sialylation are tissue and context specific.
Plasma APOE undergoes desialylation and is less glycosylated and sialylated than the cellular form.
- Protein Refseq
- NP_000032.1; NP_001289617.1; NP_001289618.1; NP_001289619.1; NP_001289620.1
Recommended Products
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-072 | Recombinant Anti-human APOE VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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