Mouse Anti-ApoE (clone W25-2E8) scFv-Fc Chimera
CAT#: VS-0125-FY51
anti-ApoE scFv-Fc is a recombinant single-chain antibody-Fc fusion variant targeting human apolipoprotein E (ApoE). This molecule typically consists of a small single-chain antibody (scFv) linked to the human IgG Fc portion to enhance stability and efficacy. anti-ApoE scFv-Fc is a promising antibody molecule for the study and potential treatment of diseases such as Alzheimer's disease. It combines the advantages of a small size and high affinity of scFv with the functional capabilities of the Fc region, making it a multifunctional biopharmaceutical candidate. Future research may further explore its specific roles and mechanisms in therapy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/1270_D3_2_selected.jpg
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- W25-2E8
- Applications
- ELISA, Blocking, Surface Plasmon Resonance
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ApoE is closely related to the pathogenesis of neurodegenerative diseases such as Alzheimer's disease; therefore, antibodies targeting ApoE may have potential therapeutic significance.
Target
- Alternative Names
- Apolipoprotein E; APO-E; Alzheimer Disease 2 (APOE*E4-Associated, Late Onset); Apolipoprotein E3; LDLCQ5; ApoE4; LPG; AD2
- Gene ID
- 348
- UniProt ID
- P02649
- Sequence Similarities
- Belongs to the apolipoprotein A1/A4/E family.
- Post Translation Modifications
- APOE exists as multiple glycosylated and sialylated glycoforms within cells and in plasma.
The extent of glycosylation and sialylation are tissue and context specific.
Plasma APOE undergoes desialylation and is less glycosylated and sialylated than the cellular form.
- Protein Refseq
- NP_000032.1; NP_001289617.1; NP_001289618.1; NP_001289619.1; NP_001289620.1
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
See other products for "APOE"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1659z | Mouse Anti-APOE Recombinant Antibody (clone 41D9) | WB, ELISA, FC, ICC, IF, IHC, IP | Mouse IgG1, κ |
| HPAB-N0315-YC | Mouse Anti-APOE Recombinant Antibody (HPAB-N0315-YC) | ELISA, WB | Mouse IgG |
| HPAB-N0316-YC | Mouse Anti-APOE Recombinant Antibody (HPAB-N0316-YC) | ELISA, WB | Mouse IgG |
| HPAB-N0317-YC | Mouse Anti-APOE Recombinant Antibody (HPAB-N0317-YC) | IP, ELISA, WB | Mouse IgG |
| VS7-HM120 | Mouse Anti-APOE Recombinant Antibody (clone CBL044HM) | WB, IHC-p, IF, FCM, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-072 | Recombinant Anti-human APOE VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0976CLV | Human Anti-APOE Recombinant Antibody (TAB-0976CLV) | ELISA, IP | Human IgG |
| TAB-0976CLV-F(E) | Human Anti-APOE Recombinant Antibody; Fab Fragment (TAB-0976CLV-F(E)) | ELISA, IP | Human Fab |
| TAB-0976CLV-S(P) | Human Anti-APOE Recombinant Antibody; scFv Fragment (TAB-0976CLV-S(P)) | ELISA, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-024CQ | Recombinant Mouse Anti-APOE Antibody | ELISA, BL | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0215 | Hi-Affi™ Rabbit Anti-APOE Recombinant Antibody (clone DS215AB) | FC, IHC-P, IP, WB | Rabbit IgG |
| MOR-4534 | Hi-Affi™ Rabbit Anti-APOE Recombinant Antibody (clone TH42DS) | WB, IF, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0315-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0315-YC-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-N0316-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0316-YC-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-N0317-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0317-YC-S(P)) | IP, ELISA, WB | Mouse scFv |
| HPAB-N0318-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0318-YC-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0115CQ-S(P) | Mouse Anti-APOE Recombinant Antibody (clone 2E8); scFv Fragment | ELISA, Block | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0315-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0315-YC-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-N0316-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0316-YC-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-N0317-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0317-YC-F(E)) | IP, ELISA, WB | Mouse Fab |
| HPAB-N0318-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0318-YC-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0115CQ-F(E) | Mouse Anti-APOE Recombinant Antibody (clone 2E8); Fab Fragment | ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY16 | AbPlus™ Anti-APOE Magnetic Beads (VS-0424-XY16) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY462 | Anti-APOE Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC24 | Recombinant Anti-APOE Eliminating Antibody, pH-Sensitive (2E8 var.) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
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