Rabbit Anti-BCR Recombinant Antibody (clone R02-6I0) (CAT#: VS3-FY1975)
The R02-6I0 recombinant monoclonal antibody is designed to target human BCR. It cross-reacts with rat. It is suitable for use in a variety of assays, including WB, IHC-P, IP. This Bcr antibody has been rigorously validated and is widely used in western blot analysis of Bcr in A549, HL-60, U2OS, C6 lysates.
Specific Inquiry
WB
Figure 1 Anti-BCR Antibody (VS3-FY1975) in WB.
The Bcr expression in A549, HL-60, U2OS, C6 lysates were detected using the anti-Bcr by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human Bcr
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat BCR
- Species Reactivity
- Human, Rat
- Clone
- R02-6I0
- Applications
- Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 143 kDa, while the observed molecular weight stands at 160 kDa.
- Related Disease
- Leukemia, Chronic Myeloid and B-Lymphoblastic Leukemia/Lymphoma With T(9;22)(Q34.1;Q11.2)
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunoprecipitation: 1/20
Target
- Alternative Names
- BCR, RhoGEF And GTPase Activating Protein; Renal Carcinoma Antigen NY-REN-26; Breakpoint Cluster Region; EC 2.7.11.1; D22S11; BCR1; Breakpoint Cluster Region Protein
- Gene ID
- 613
- UniProt ID
- P11274
- Cellular Localization
- Cell projection, Synapse
- Post Translation Modifications
- Autophosphorylated.
Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity.
Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.
- Protein Refseq
- NP_004318.3; NP_067585.2
- Function
- Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form.
The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1.
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
Asthma
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Amyotrophic Lateral Sclerosis
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Chimeric Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-104 | Recombinant Anti-BCR Antibody | ELISA, WB, IP, FuncS | IgG |
| MHH-104 | Recombinant Human Anti-BCR Antibody | ELISA, IP, FuncS | IgG |
| HPAB-0267-YC | Human Anti-BCR Recombinant Antibody (HPAB-0267-YC) | ELISA | Chimeric (mouse/human) IgG |
| HPAB-0268-YC | Human Anti-BCR Recombinant Antibody (HPAB-0268-YC) | ELISA | Humanized IgG |
| VS3-WK119 | Mouse Anti-BCR Recombinant Antibody (clone G12-E11) | WB, ELISA | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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