Human Anti-BDNF Recombinant Antibody (clone R3BH1) (CAT#: HPAB-0351-FY)
This product is a recombinant antibody that recognizes Human BDNF. The monoclonal antibody R3BH1 reacts with the epitope (C-terminus) of BDNF. Anti-BDNF antibody R3BH1 and TrkB-Fc molecule inhibits TrkB receptor activation and downstream signalling mediated by BDNF, as measured by phosphorylated pERK activity.
Specific Inquiry
ELISA
Figure 1 Anti-BDNF R3BH1 displaces TrkB receptor bound BDNF in a competition HTRF assay.
Inhib
Figure 2 SPR anti-BDNF R3BH1 inhibition of BDNF binding to immobilised p75NTR.
Inhib
Figure 3 Cell based ERK phosphorylation assay in U20S TrkB/p75NTR cells.
Anti-BDNF antibody R3BH1 and TrkB-Fc molecule inhibits TrkB receptor activation and downstream signalling mediated by BDNF, as measured by phosphorylated pERK activity.
FuncS
Figure 4 Ligand binding assay using a fluorescent readout for total BDNF measured in plasma following intravenous dosing of rats with anti-BDNF antibody R3BH1 and humanised anti-BDNF molecule, B30.
FuncS
Figure 5 In vitro electrophysiology in dissociated dorsal root ganglion (DRG) neurones.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (chicken/human)
- Type
- Chimeric (chicken/human) lgG1, λ
- Specificity
- Human BDNF
- Species Reactivity
- Human
- Clone
- R3BH1
- Applications
- ELISA, Inhib, FuncS, Neut
- Related Disease
- Parkinson's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Inhibition, Functional Assay, Neutralization.
Target
- Alternative Names
- Brain Derived Neurotrophic Factor; Neurotrophin; Abrineurin; Brain-Derived Neurotrophic Factor; ANON2; BULN2;
- Gene ID
- 627
- UniProt ID
- P23560
Related Resources
Cocaine Addiction
Alcoholism
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone R3BH1"
See other products for "BDNF"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-107 | Recombinant Anti-human BDNF Antibody | ELISA, WB, Dot, FuncS | IgG |
| MOB-0467MZ | Mouse Anti-BDNF Recombinant Antibody (clone 46039.22) | ELISA, IHC-P, WB | Mouse IgG1 |
| MRO-0166-CN | Rabbit Anti-BDNF Recombinant Antibody (clone CBACN-065) | WB, IHC, IF | Rabbit IgG |
| MRO-1686-CN | Rabbit Anti-BDNF Polyclonal Antibody (MRO-1686-CN) | WB, IF, IHC | Rabbit IgG |
| VS3-XY120 | Mouse Anti-BDNF Recombinant Antibody (clone 3D9C5) | ELISA, WB, ICC | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-107-F(E) | Recombinant Anti-human BDNF Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| MHH-107-F(E) | Recombinant Human Anti-human BDNF Antibody Fab Fragment | ELISA, WB, Neut, FuncS | Fab |
| HPAB-0351-FY-F(E) | Human Anti-BDNF Recombinant Antibody (clone R3BH1); Fab Fragment | Block | Chimeric (chicken/human) Fab, λ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-107-S(P) | Recombinant Anti-human BDNF Antibody scFv Fragment | FC, RIA, Biosensors, FuncS | scFv |
| MHH-107-S(P) | Recombinant Human Anti-human BDNF Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| HPAB-0351-FY-S(P) | Chicken Anti-BDNF Recombinant Antibody (clone R3BH1); scFv Fragment | Block | Chicken scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1247CL | Anti-Human BDNF Recombinant Antibody (B30) | Inhib, FuncS | Humanized antibody |
| TAB-1248CL | Anti-Human BDNF Recombinant Antibody (B20) | Inhib, FuncS | Humanized antibody |
| TAB-1247CL-S(P) | Anti-Human BDNF Recombinant Antibody scFv Fragment (B30) | Inhib, FuncS | Humanized antibody |
| TAB-1248CL-S(P) | Anti-Human BDNF Recombinant Antibody scFv Fragment (B20) | ELISA, Inhib | Humanized antibody |
| TAB-1249CL-S(P) | Anti-Human BDNF Recombinant Antibody scFv Fragment (B18) | ELISA, Inhib | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0825MZ | Chicken Anti-BDNF Polyclonal IgY | ELISA | Chicken antibody |
| BRD-1149MZ | Chicken Anti-Human BDNF Polyclonal IgY | ELISA | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-044CQ | Mouse Anti-BDNF Recombinant Antibody (clone CBL263) | ELISA, WB, Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0351 | Hi-Affi™ Rabbit Anti-BDNF Recombinant Antibody (clone DS351AB) | WB, IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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