Mouse Anti-C5 Recombinant Antibody Hexamer (VS-0924-YC104), CDC Enhanced
CAT#: VS-0924-YC104
The product is a hexameric anti-C5 mouse antibody with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human C5 and includes hexamerization-enhancing mutations that promote hexamer formation. These mutations facilitate optimal C1q binding and boost CDC.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A549, Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
❮
❯
Specifications
- Immunogen
- Purified human C5
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human C5
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, Inhib, CDC
- Conjugate
- None
- Related Disease
- Bacterial sepsis, chronic IC diseases, and psoriasis
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- C5; complement component 5; C5D; C5a; C5b; ECLZB; CPAMD4; complement C5; prepro-C5; C5a anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein
- Gene ID
- 727
- UniProt ID
- P01031
- Long Name
- Complement C5
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn741, Asn911, Asn1115, and Asn1630 ( NX_P01031 [NX_P01031-1] )
- Protein Refseq
- NP_001304092.1; NP_001304093.1; NP_001726.2
- Function
- Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex.
C5b has a transient binding site for C6.
The C5b-C6 complex is the foundation upon which the lytic complex is assembled. CO5_HUMAN,P01031
[C5a anaphylatoxin]: Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process.
Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0924-YC104. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Systemic Lupus Erythematosus
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "C5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-934 | Recombinant Human Anti-C5 Antibody scFv Fragment | ELISA, SPR, Inhib | scFv |
| HPAB-0609-CN-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0609-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0611-CN-S(P) | Rabbit Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0611-CN-S(P)) | WB, ELISA, FC | Rabbit scFv |
| HPAB-0612-CN-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0612-CN-S(P)) | WB, ELISA, FC | Humanized scFv |
| HPAB-0613-CN-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0613-CN-S(P)) | WB, ELISA, FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1366CL | Mouse Anti-C5 Recombinant Antibody (TAB-1366CL) | ELISA, Inhib | Mouse IgG |
| TAB-1367CL | Mouse Anti-C5 Recombinant Antibody (TAB-1367CL) | ELISA, Inhib | Mouse IgG |
| TAB-1368CL | Mouse Anti-C5 Recombinant Antibody (TAB-1368CL) | ELISA | Mouse IgG |
| TAB-1369CL | Mouse Anti-C5 Recombinant Antibody (TAB-1369CL) | ELISA, Inhib | Mouse IgG |
| TAB-1370CL | Mouse Anti-C5 Recombinant Antibody (TAB-1370CL) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1372CL | Human Anti-C5 Recombinant Antibody (TAB-1372CL) | Inhib, FuncS | Humanized antibody |
| TAB-1373CL | Human Anti-C5 Recombinant Antibody (TAB-1373CL) | IB, CDC, Inhib | Humanized IgG |
| TAB-1374CL | Human Anti-C5 Recombinant Antibody (TAB-1374CL) | ELISA, CDC, Inhib | Humanized IgG |
| TAB-1375CL | Human Anti-C5 Recombinant Antibody (TAB-1375CL) | CDC, Inhib | Humanized IgG |
| TAB-1373CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1373CL-S(P)) | IB, Inhib | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-082CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL249) | ELISA, Neut | Mouse IgG2a |
| NEUT-083CQ | Mouse Anti-C5 Recombinant Antibody (clone MM0608-6H13) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-084CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL030) | ELISA, WB, Neut | Mouse IgG1 |
| NEUT-085CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL250) | ELISA, WB, IHC, FuncS | Mouse IgG1 |
| NEUT-086CQ | Mouse Anti-C5 Recombinant Antibody (clone G25/2) | ELISA, IP, WB, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-088CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL771) | WB, Block, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4104 | Hi-Affi™ Rabbit Anti-C5 Recombinant Antibody (clone SI175DS) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-453CQ | Anti-Human C5 Recombinant Antibody (TAB-453CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, λ2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0609-CN-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0609-CN-F(E)) | ELISA, Block | Humanized Fab |
| HPAB-0611-CN-F(E) | Rabbit Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0611-CN-F(E)) | WB, ELISA, FC | Rabbit Fab |
| HPAB-0612-CN-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0612-CN-F(E)) | WB, ELISA, FC | Humanized Fab |
| HPAB-0613-CN-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0613-CN-F(E)) | WB, ELISA, FC | Humanized Fab |
| HPAB-0614-CN-F(E) | Mouse Anti-C5 Recombinant Antibody (clone m5G1.1); Fab Fragment | WB, ELISA, IF, IP, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0652LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0652LY) | IP, RIA, ELISA, WB | Mouse IgG |
| HPAB-0653LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0653LY) | IP, RIA, ELISA, WB | Mouse IgG |
| HPAB-0654LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0654LY) | IP, RIA, ELISA, WB | Mouse IgG |
| HPAB-0655LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0655LY) | IP, RIA, ELISA, WB | Mouse IgG |
| HPAB-0656LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0656LY) | IP, RIA, ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-559 | Recombinant Llama Anti-C5 Single Domain Antibody (PABC-559) | ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-453CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-453CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-008 | Afuco™ Anti-C5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-008) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-436CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-436CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY36 | AbPlus™ Anti-C5 Magnetic Beads (5G1.1CB) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC103 | Human Anti-C5 Recombinant Antibody Hexamer (VS-0924-YC103), CDC Enhanced | IB, CDC, Inhib | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY137 | Mouse Anti-NHP C5 Recombinant Antibody (clone aE11) | ELISA | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY95 | Human Anti-C5 (clone BB5.1) scFv-Fc Chimera | FC, IA, IF, IP, IHC, FuncS | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY889 | Anti-C5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY890 | Anti-Rat C5 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, IP, WB, IHC, IF, FuncS
-3-1.png)
Application: ELISA, FC, WB, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
-2.png)
Application: ELISA
Application: FC
Application: ELISA
Application: Inhib, FC, WB
Application: ELISA, FuncS
Application: ELISA, Neut
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
