SmartAb™ Recombinant Anti-C5 pH-dependent Antibody (VS-0825-YC25)
CAT#: VS-0825-YC25
The anti-C5 pH-dependent antibody (VS-0825-YC25) targets both human and Cynomolgus C5 in a pH-dependent manner, with its affinity remaining high at neutral pH but weakening at a lower pH, such as within the acidic environment of endosomes. The anti-C5 acid-switched antibody was engineered by incorporating histidine residues into its variable regions. The introduction of histidine substitutions within its Complementarity-Determining Regions (CDRs) enables pH-responsive antigen binding, which enhances C5 clearance. The antibody operates in a cyclical manner, binding C5 in the extracellular fluid and releasing it in acidified endosomes. As C5 proteins are key components of the complement system, their high homology and shared function make the cynomolgus monkey a valuable animal model for studying human complement-related diseases and therapies.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A549, Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
❮
❯
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG1 kappa
- Specificity
- Human and Cynomolgus C5
- Species Reactivity
- Human, Cynomolgus
- Applications
- WB, ELISA, FC, Neut
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0825-YC25. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Systemic Lupus Erythematosus
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "C5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008 | Anti-Human C5 Recombinant Antibody (TAB-008) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG2 / G4 - kappa |
| TAB-1372CL-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1372CL-F(E)) | Inhib, FuncS | Humanized Fab |
| TAB-1373CL-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1373CL-F(E)) | IB, Inhib | Humanized Fab |
| TAB-1374CL-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1374CL-F(E)) | ELISA, Inhib | Humanized Fab |
| TAB-1375CL-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1375CL-F(E)) | ELISA, Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1366CL-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1366CL-F(E)) | ELISA, Inhib | Mouse Fab |
| TAB-1367CL-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1367CL-F(E)) | ELISA, Inhib | Mouse Fab |
| TAB-1368CL-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1368CL-F(E)) | ELISA | Mouse Fab |
| TAB-1369CL-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1369CL-F(E)) | ELISA, Inhib | Mouse Fab |
| TAB-1370CL-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1370CL-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-082CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL249) | ELISA, Neut | Mouse IgG2a |
| NEUT-083CQ | Mouse Anti-C5 Recombinant Antibody (clone MM0608-6H13) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-084CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL030) | ELISA, WB, Neut | Mouse IgG1 |
| NEUT-085CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL250) | ELISA, WB, IHC, FuncS | Mouse IgG1 |
| NEUT-086CQ | Mouse Anti-C5 Recombinant Antibody (clone G25/2) | ELISA, IP, WB, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-088CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL771) | WB, Block, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4104 | Hi-Affi™ Rabbit Anti-C5 Recombinant Antibody (clone SI175DS) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-453CQ | Anti-Human C5 Recombinant Antibody (TAB-453CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, λ2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0609-CN | Human Anti-C5 Recombinant Antibody (HPAB-0609-CN) | ELISA, Block | Humanized IgG |
| HPAB-0611-CN | Rabbit Anti-C5 Recombinant Antibody (HPAB-0611-CN) | PK, SPR, IF, ELISA, WB, FC | Rabbit IgG |
| HPAB-0612-CN | Human Anti-C5 Recombinant Antibody (HPAB-0612-CN) | PK, WB, ELISA, FC | Humanized IgG |
| HPAB-0613-CN | Human Anti-C5 Recombinant Antibody (HPAB-0613-CN) | WB, ELISA, FC | Humanized IgG |
| HPAB-0614-CN | Mouse Anti-C5 Recombinant Antibody (clone m5G1.1) | Inhib, FuncS, WB, ELISA, IF, IP, Block | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0609-CN-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0609-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0611-CN-S(P) | Rabbit Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0611-CN-S(P)) | WB, ELISA, FC | Rabbit scFv |
| HPAB-0612-CN-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0612-CN-S(P)) | WB, ELISA, FC | Humanized scFv |
| HPAB-0613-CN-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0613-CN-S(P)) | WB, ELISA, FC | Humanized scFv |
| HPAB-0614-CN-S(P) | Mouse Anti-C5 Recombinant Antibody (clone m5G1.1); scFv Fragment | WB, ELISA, IF, IP, Block | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0652LY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0652LY-F(E)) | IP, RIA, ELISA, WB | Mouse Fab |
| HPAB-0653LY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0653LY-F(E)) | IP, RIA, ELISA, WB | Mouse Fab |
| HPAB-0654LY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0654LY-F(E)) | IP, RIA, ELISA, WB | Mouse Fab |
| HPAB-0655LY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0655LY-F(E)) | IP, RIA, ELISA, WB | Mouse Fab |
| HPAB-0656LY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0656LY-F(E)) | IP, RIA, ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-559 | Recombinant Llama Anti-C5 Single Domain Antibody (PABC-559) | ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-453CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-453CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-008 | Afuco™ Anti-C5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-008) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-436CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-436CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY36 | AbPlus™ Anti-C5 Magnetic Beads (5G1.1CB) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC103 | Human Anti-C5 Recombinant Antibody Hexamer (VS-0924-YC103), CDC Enhanced | IB, CDC, Inhib | Antibody hexamer |
| VS-0924-YC104 | Mouse Anti-C5 Recombinant Antibody Hexamer (VS-0924-YC104), CDC Enhanced | ELISA, Inhib, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY137 | Mouse Anti-NHP C5 Recombinant Antibody (clone aE11) | ELISA | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY95 | Human Anti-C5 (clone BB5.1) scFv-Fc Chimera | FC, IA, IF, IP, IHC, FuncS | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY889 | Anti-C5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY890 | Anti-Rat C5 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC38 | Recombinant Anti-C5 Eliminating Antibody, pH-Sensitive (VS-0625-YC38) | Antigen-Sweeping In Vivo. | Mouse IgG2/IgG4 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC14 | SmartAb™ Recombinant Anti-C5 pH-dependent Antibody (VS-0825-YC14) | ELISA, FC, IP IF, Neut, WB | Human IgG2/G4 kappa |
| VS-0825-YC21 | SmartAb™ Recombinant Anti-C5 pH-dependent Antibody (Clone BB5.1) | FC, IA, IF, IP, IHC | Mouse IgG1 |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
-2.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, IHC, FC, Cyt, ELISA
Application: IHC, ELISA, FC, WB, ADCC, FuncS
Application: ELISA, Inhib, FuncS
Application: ELISA, FC, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
