Human Anti-C5 (clone BB5.1) scFv-Fc Chimera (CAT#: VS-0125-FY95)
Anti-C5 scFv-Fc is a type of antibody obtained in vitro through recombinant technology, monoclonal antibody techniques, or other synthetic biological methods. Research teams specifically clone the DNA sequences encoding the corresponding antibody fragment (scFv) and produce the fusion protein using expression systems such as viral vectors or cell cultures. This antibody can specifically bind to the C5 antigen, enhancing the sensitivity and specificity of detection in complex biological samples.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A549, Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- BB5.1
- Applications
- Flow Cytometry, Immunoassay, Immunofluorescence, Immunoprecipitation, Immunohistochemistry, Functional Assay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The function is mainly related to improving detection sensitivity and reducing background signals and contaminants.
Target
- Alternative Names
- C5, C5D, C5a, C5b, CPAMD4, ECLZB, complement component 5, complement C5
- Gene ID
- 727
- UniProt ID
- P01031
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn741, Asn911, Asn1115, and Asn1630
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect CO5_HUMAN (1147)
Glycosylation from GlyGen 5 sites, 27 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001304092.1; NP_001304093.1; NP_001726.2
- Function
- Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex.
C5b has a transient binding site for C6.
The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
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Related Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-901 | Anti-Human C5 Recombinant Antibody (Pexelizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | scFv |
| TAB-008 | Anti-Human C5 Recombinant Antibody (TAB-008) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG2 / G4 - kappa |
| TAB-1381CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1381CL-S(P)) | SPR | Humanized scFv |
| TAB-1372CL-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1372CL-F(E)) | Inhib, FuncS | Humanized Fab |
| TAB-1373CL-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1373CL-F(E)) | IB, Inhib | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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