Rabbit Anti-CAMK1 Recombinant Antibody (clone R06-7C4) (CAT#: VS3-FY1632)
Clone R06-7C4 is a rabbit recombinant monoclonal antibody that attaches to human CAMK1. It cross-reacts with mouse, rat. This CaMK1 antibody has been rigorously validated and is widely used in western blot analysis of CaMK1 in rat brain, C6, 3T3 lysates.
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WB
Figure 1 Anti-CAMK1 Antibody (VS3-FY1632) in WB.
The CaMK1 expression in rat Brain, C6, 3T3 lysates were detected using the anti-CaMK1 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human CaMKI
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CAMK1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R06-7C4
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 41 kDa, while the observed molecular weight stands at 41 kDa.
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Calcium/Calmodulin Dependent Protein Kinase I; CaM Kinase I Alpha; EC 2.7.11.17; CaMKI-Alpha; CaM-KI; Calcium/Calmodulin-Dependent Protein Kinase Type 1; CaM Kinase I; EC 2.7.11; CAMKI
- Gene ID
- 8536
- UniProt ID
- Q14012
- Sequence Similarities
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Phosphorylated by CaMKK1 and CaMKK2 on Thr-177.
- Protein Refseq
- NP_003647.1
- Function
- Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x2-[ST]-x3-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca²⁺ elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "CAMK1"
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IgG Antibodies
Rabbit Monoclonal Antibodies
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3291z | Mouse Anti-CAMK1 Recombinant Antibody (clone 40G3) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| MOB-0296CT | Mouse Anti-CAMK1 Recombinant Antibody (clone EML819) | WB | Mouse IgG1 |
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