Rabbit Anti-CD3D Recombinant Antibody (VS3-CJ339)
CAT#: VS3-CJ339
This product is a rabbit antibody that recognizes CD3D.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line JURKAT shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71778/1970_F1_3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167286-CD3D
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CD3D
- Species Reactivity
- Human
- Applications
- WB, ICC, IHC, IP, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Flow Cytometry.
Target
- Alternative Names
- T3D; IMD19; CD3DELTA; CD3-DELTA; T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; CD_antigen: CD3d
- Gene ID
- 915
- UniProt ID
- P04234
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
- Protein Refseq
- NP_000723.1; NP_001035741.1
- Function
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098).
In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456).
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Related Diseases
Primary Immunodeficiency
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| HPAB-594-FY-S(P) | Human Anti-CD3D Recombinant Antibody scFv Fragment (HPAB-594-FY-S(P)) | ELISA | Human scFv |
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| HPAB-0381-FY-S(P) | Human Anti-CD3D Recombinant Antibody; scFv Fragment (HPAB-0381-FY-S(P)) | FC, ELISA | Human scFv |
| HPAB-0382-FY-S(P) | Human Anti-CD3D Recombinant Antibody; scFv Fragment (HPAB-0382-FY-S(P)) | Activ | Human scFv |
| HPAB-0384-FY-S(P) | Rat Anti-CD3D Recombinant Antibody; scFv Fragment (HPAB-0384-FY-S(P)) | ELISA | Rat scFv |
| CAT | Product Name | Application | Type |
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| HPAB-594-FY-F(E) | Human Anti-CD3D Recombinant Antibody Fab Fragment (HPAB-594-FY-F(E)) | ELISA | Human Fab |
| HPAB-0703-FY-S(P) | Mouse Anti-CD3D Recombinant Antibody (clone AB002); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0381-FY-F(E) | Human Anti-CD3D Recombinant Antibody; Fab Fragment (HPAB-0381-FY-F(E)) | FC, ELISA | Human Fab |
| HPAB-0382-FY-F(E) | Human Anti-CD3D Recombinant Antibody; Fab Fragment (HPAB-0382-FY-F(E)) | Activ | Human Fab |
| HPAB-0384-FY-F(E) | Rat Anti-CD3D Recombinant Antibody; Fab Fragment (HPAB-0384-FY-F(E)) | ELISA | Rat Fab |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1169 | Anti-Rat CD3D Immunohistochemistry Kit | IHC | |
| VS-0525-XY1170 | Anti-Human CD3D Immunohistochemistry Kit | IHC |
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