Human Anti-CD79B Recombinant Antibody (clone huMA79b) (CAT#: HPAB-1939-FY)
This product is a recombinant antibody that recognizes CD79b. The monoclonal antibody huMA79b reacts with the epitope of CD79b.
Specific Inquiry
FuncS
Figure 1 Shows a graph of inhibition of in vivo tumor growth in a BJAB-luciferase xenograft mode.
Administration of anti-CD79b antibodies/chMA79b-SMCC-DM1, drug load was approximately 2.9 and huMA79b L2/H3-SMCC-DM1, drug load was approximately 2.4 to SCID mice having human B cell tumors significantly inhibited tumor growth.
FuncS
Figure 2 Shows a graph of inhibition of in vivo tumor growth in a Granta-519 (Human Mantle Cell Lymphoma) xenograft model.
Administration of anti-CD79b antibodies/chMA79b-SMCC-DM1, drug load was approximately 3.6 and huMA79b.v17-SMCC-DM1, drug load was approximately 3.4 to SCID mice having human B cell tumors significantly inhibited tumor growth.
Inhib
Figure 3 Shows a graph of inhibition of in vivo tumor growth in a BJAB-luciferase (Burkitt's Lymphoma) xenograft model.
Administration of anti-CD79b TDCs conjugated to different linker drug moieties or anti-CD79b antibody (huMA79b) to SCID mice having human B cell tumors, significantly inhibited tumor growth.
Inhib
Figure 4 Shows a graph of inhibition of in vivo tumor growth in a WSU-DLCL2 (Diffuse Large Cell Lymphoma) xenograft model .
Administration of anti-CD79b TDCs conjugated to different linker drug moieties or anti-CD79b antibody (huMA79b) to SCID mice having human B cell tumors, significantly inhibited tumor growth.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG1, κ
- Specificity
- Human CD79b
- Species Reactivity
- Human
- Clone
- huMA79b
- Applications
- FuncS, Inhib
- Related Disease
- B-cell malignancy
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CD79b antibody has been reported in applications of Functional Assay, Inhibition.
Target
- Alternative Names
- CD79b Molecule; CD79B Antigen (Immunoglobulin-Associated Beta); CD79b Molecule, Immunoglobulin-Associated Beta; Immunoglobulin-Associated B29 Protein; B-Cell-Specific Glycoprotein B29; Ig-Beta
- Gene ID
- 974
- UniProt ID
- P40259
Related Resources
BCR Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-897 | Humanized Anti-CD79B Recombinant Antibody (clone Polatuzumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Humanized (from mouse) IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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