Anti-CSF1R Antibody Prodrug, Protease Activated (VS-1025-YC42)

Name: Anti-CSF1R Antibody Prodrug, Protease Activated (VS-1025-YC42)
SKU: VS-1025-YC42
Rating: 5 (1 reviews)

CAT#: VS-1025-YC42

The Anti-CSF1R Antibody Prodrug, Protease Activated (VS-1025-YC42) is an antibody prodrug comprised of a recombinant mouse antibody targeting human CSF1R, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CSF1R protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CSF1R effectively. CSF1R (Colony Stimulating Factor 1 Receptor) is a receptor tyrosine kinase that is primarily involved in the survival and differentiation of macrophages and monocytes. In the tumor context, CSF1R signaling promotes the recruitment of tumor-associated macrophages (TAMs), which create an immunosuppressive microenvironment that supports tumor growth, angiogenesis, and metastasis. Inhibitors of CSF1R are explored as a strategy to reprogram the tumor microenvironment.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/201_C4_2_selected.jpg

Normal Tissue Figure 2 IHC staining of human hippocampus

Immunohistochemical staining of human hippocampus shows cytoplasmic positivity in neuronal cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/29746_B_7_6_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_B_9_5.jpg

Normal Tissue Figure 4 Colon

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_3.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_5.jpg

Normal Tissue Figure 6 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_6_6.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (BEWO, SK-BR-3)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182578-CSF1R

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Specifications

Host Animal
Mouse

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human CSF1R

Target
CSF1R

Species Reactivity
Human

Isotype
IgG

Epitope
CSF1R-ECD

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants.

Alternative Names
FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R

Gene ID
1436

UniProt ID
P07333

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Datasheet

Datasheet - VS-1025-YC42.pdf

MSDS

MSDS - VS-1025-YC42.pdf

COA

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