Human Anti-CSF1R (clone RG7155) scFv-Fc Chimera
CAT#: VS-0425-FY97
This scFv-Fc construct targets CSF1R (M-CSF receptor), a receptor tyrosine kinase essential for the survival and function of macrophages and monocytes. By inhibiting CSF1R signaling, it can regulate macrophage activity and has potential therapeutic applications in cancer and inflammatory disorders.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/201_C4_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human hippocampus
Immunohistochemical staining of human hippocampus shows cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/29746_B_7_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (BEWO, SK-BR-3)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182578-CSF1R
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CSF1R
- Species Reactivity
- Human
- Clone
- RG7155
- Applications
- Flow Cytometry
- Related Disease
- Alzheimer's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Colony Stimulating Factor 1 Receptor; McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog; Proto-Oncogene C-Fms; CSF-1 Receptor; CD115 Antigen; EC 2.7.10.1; M-CSF-R; CSF-1R; FMS; Macrophage Colony Stimulating Factor I Receptor
- Gene ID
- 1436
- UniProt ID
- P07333
- Long Name
- Colony Stimulating Factor 1 Receptor
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-559 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-559 and Tyr-807 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-697 and Tyr-921 is important for interaction with GRB2. Phosphorylation at Tyr-721 is important for interaction with PIK3R1. Phosphorylation at Tyr-721 and Tyr-807 is important for interaction with PLCG2. Phosphorylation at Tyr-974 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation.
- Protein Refseq
- NP_001275634.1; NP_001336665.1; NP_001362249.1; NP_001362250.1; NP_005202.2
- Function
- Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1863z | Mouse Anti-CSF1R Recombinant Antibody (clone 32G11) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| HPAB-0574-CN | Mouse Anti-CSF1R Recombinant Antibody (HPAB-0574-CN) | ELISA, Block | Mouse IgG |
| HPAB-2085LY | Human Anti-CSF1R Recombinant Antibody (clone 2F11-d8) | ELISA | Human IgG |
| HPAB-2086LY | Human Anti-CSF1R Recombinant Antibody (clone 2F11-f12) | ELISA | Human IgG |
| HPAB-2087LY | Human Anti-CSF1R Recombinant Antibody (clone 2F11-g1) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H23 | Anti-Human CSF1R Recombinant Antibody (TAB-H23) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
| TAB-076MZ-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-076MZ-S(P)) | WB | Human scFv |
| TAB-078MZ-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-078MZ-S(P)) | ELISA | Humanized scFv |
| TAB-076MZ-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (TAB-076MZ-F(E)) | WB | Humanized Fab |
| TAB-011ML | Anti-Human CSF1R Recombinant Antibody (TAB-011ML) | ELISA, IHC, FC, IP, IF, Inhib | IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-178CL | Afuco™ Anti-CSF1R Recombinant Antibody (AFC-178CL), ADCC Enhanced | ELISA, WB | Human IgG1 |
| AFC-TAB-H23 | Afuco™ Anti-CSF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H23) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-011ML | Afuco™ Anti-CSF1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-011ML) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-077MZ | Mouse Anti-CSF1R Recombinant Antibody (TAB-077MZ) | ELISA | Mouse IgG2a, κ |
| TAB-079MZ | Anti-Mouse CSF1R Recombinant Antibody (AFS98) | FC | |
| TAB-077MZ-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-077MZ-S(P)) | ELISA | Mouse scFv |
| TAB-077MZ-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (TAB-077MZ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-508CQ | Mouse Anti-CSF1R Recombinant Antibody (clone CBL141) | Neut, WB | Mouse IgG1 |
| NEUT-509CQ | Mouse Anti-CSF1R Recombinant Antibody (clone CBL809) | WB, Neut | Mouse IgG1 |
| NEUT-510CQ | Mouse Anti-CSF1R Recombinant Antibody (clone MM0467-5V36) | WB, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0825 | Hi-Affi™ Rabbit Anti-CSF1R Recombinant Antibody (clone DS825AB) | ELISA | Rabbit IgG |
| MOR-4112 | Hi-Affi™ Rabbit Anti-CSF1R Recombinant Antibody (clone SI183DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0288-FY-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0288-FY-F(E)) | ELISA | Human Fab |
| HPAB-0301-FY-F(E) | Human Anti-CSF1R Recombinant Antibody (clone huAb6); Fab Fragment | Block, ELISA | Humanized Fab |
| HPAB-0302-FY-F(E) | Human Anti-CSF1R Recombinant Antibody (clone Fab0311); Fab Fragment | ADCC, ELISA | Humanized Fab |
| HPAB-0963-FY-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0963-FY-S(P)) | WB, FC, ELISA | Human scFv |
| HPAB-AP311-YC-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-AP311-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP311-YC-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-AP311-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0060-YC-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-J0060-YC-S(P)) | ELISA, Block, ADCC | Human scFv |
| HPAB-J0061-YC-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-J0061-YC-S(P)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Human scFv |
| HPAB-J0062-YC-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-J0062-YC-S(P)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Humanized scFv |
| HPAB-J0063-YC-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-J0063-YC-S(P)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC551 | Recombinant Anti-CSF1R Vesicular Antibody, EV Displayed (VS-0425-YC551) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1705 | Anti-CSF1R Immunohistochemistry Kit | IHC | |
| VS-0525-XY1706 | Anti-Mouse CSF1R Immunohistochemistry Kit | IHC |
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