Recombinant Human Antibody (RG7155) is capable of binding to CSF1R, expressed in Chinese Hamster Ovary cells (CHO). This antibody could inhibit CSF-1 receptor (CSF-1R) activation.
Figure 1 Luminescence-based viability of M(IL-10), 6d differentiated under hypoxia (HPX) or normoxia (NMX) and inhibited for further 8d with 1 µg/mL RG7155 compared to IgG.
Pradel, L.P., Ooi, C.H., Romagnoli, S., et al. (2016). Macrophage susceptibility to emactuzumab (RG7155) treatment. Molecular Cancer Therapeutics, 15(12), 3077-3086.
Figure 2 Expression (log2-transformed RPKM) values of baseline and treated tumor biopsy samples from 31 patients enrolled in the Phase 1 Trial for CSF1-R and CD163.
Pradel, L.P., Ooi, C.H., Romagnoli, S., et al. (2016). Macrophage susceptibility to emactuzumab (RG7155) treatment. Molecular Cancer Therapeutics, 15(12), 3077-3086.
Figure 3 RG7155 inhibits monocyte survival during differentiation by TCM.
Monocytes were cultured for 6 days in TCM with 30 mg/ml RG7155 or huIgG, and survival was analyzed by DAPI staining. Columns depicted were normalized to viable cells in the corresponding huIgG control (at least three donors; mean ± SEM; pairwise t test; *p < 0.05, **p < 0.01). The corresponding M-CSF/GM-CSF ratio of TCM is indicated on the secondary scale (blue squares). TC-Macs were classified as GM-CSF/CSF-1 polarized and are depicted by black bars at a CSF-1/GM-CSF ratio <50.
Ries, C.H., Cannarile, M.A., Sabine Hoves, S., et al. (2014). Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy. Cancer Cell, 25, 1-14.
Figure 4 Representative immunohistochemistry (IHC) images from one cynomolgus male animal is shown for each liver, colon, and lung from the vehicle-, 30 mg/kg RG7155-, and 100 mg/kg RG7155-treated groups (left).
Each group is represented by one male and one female treated once weekly for 2 weeks. Individual scores for the percent area coverage of the different cell types are shown for both animals per vehicle and dosing groups tested (right).
Ries, C.H., Cannarile, M.A., Sabine Hoves, S., et al. (2014). Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy. Cancer Cell, 25, 1-14.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H23 | Anti-Human CSF1R Recombinant Antibody (Emactuzumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
TAB-076MZ-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-076MZ-S(P)) | WB | Human scFv |
TAB-078MZ-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-078MZ-S(P)) | ELISA | Humanized scFv |
TAB-076MZ-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (TAB-076MZ-F(E)) | WB | Humanized Fab |
TAB-078MZ-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (TAB-078MZ-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-178CL | Afuco™ Anti-CSF1R Recombinant Antibody (AFC-178CL), ADCC Enhanced | ELISA, WB | Human IgG1 |
AFC-TAB-H23 | Afuco™ Anti-CSF1R ADCC Recombinant Antibody (Emactuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-011ML | Afuco™ Anti-CSF1R ADCC Recombinant Antibody (Cabiralizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-077MZ | Mouse Anti-CSF1R Recombinant Antibody (TAB-077MZ) | ELISA | Mouse IgG2a, κ |
TAB-079MZ | Anti-Mouse CSF1R Recombinant Antibody (AFS98) | FC | |
TAB-077MZ-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-077MZ-S(P)) | ELISA | Mouse scFv |
TAB-077MZ-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (TAB-077MZ-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-508CQ | Mouse Anti-CSF1R Recombinant Antibody (clone CBL141) | Neut, WB | Mouse IgG1 |
NEUT-509CQ | Mouse Anti-CSF1R Recombinant Antibody (clone CBL809) | WB, Neut | Mouse IgG1 |
NEUT-510CQ | Mouse Anti-CSF1R Recombinant Antibody (clone MM0467-5V36) | WB, Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0825 | Hi-Affi™ Rabbit Anti-CSF1R Recombinant Antibody (clone DS825AB) | ELISA | Rabbit IgG |
MOR-4112 | Hi-Affi™ Rabbit Anti-CSF1R Recombinant Antibody (clone SI183DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0574-CN | Mouse Anti-CSF1R Recombinant Antibody (HPAB-0574-CN) | ELISA, Block | Mouse IgG |
HPAB-0575-CN | Human Anti-CSF1R Recombinant Antibody (HPAB-0575-CN) | ELISA, Block | Chimeric (mouse/human) IgG4, κ |
HPAB-0576-CN | Human Anti-CSF1R Recombinant Antibody (HPAB-0576-CN) | ELISA, Block | Humanized IgG4, κ |
HPAB-0577-CN | Mouse Anti-CSF1R Recombinant Antibody (HPAB-0577-CN) | ELISA, FC | Mouse IgG |
HPAB-0579-CN | Human Anti-CSF1R Recombinant Antibody (HPAB-0579-CN) | ELISA, FC, Neut | Humanized IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0574-CN-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0574-CN-S(P)) | ELISA, Block | Mouse scFv |
HPAB-0575-CN-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0575-CN-S(P)) | ELISA, Block | Mouse scFv |
HPAB-0576-CN-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0576-CN-S(P)) | ELISA, Block | Humanized scFv |
HPAB-0577-CN-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0577-CN-S(P)) | ELISA, FC | Mouse scFv |
HPAB-0579-CN-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0579-CN-S(P)) | ELISA, FC, Neut | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0073-LS-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0073-LS-F(E)) | Block | Mouse Fab |
HPAB-0074-LS-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0074-LS-F(E)) | Block | Human Fab |
HPAB-0075-LS-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0075-LS-F(E)) | ELISA, Inhib | Mouse Fab |
HPAB-0076-LS-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0076-LS-F(E)) | ELISA, Inhib | Mouse Fab |
HPAB-0077-LS-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0077-LS-F(E)) | ELISA, Inhib | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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