Recombinant Anti-CSF1R Vesicular Antibody, EV Displayed (VS-0425-YC551) (CAT#: VS-0425-YC551)

• Application
• ELISA, FC, Neut, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• CSF1R

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Monkey

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Colony stimulating factor 1 receptor

• Biological Process
• Immunity, Inflammatory response, Innate immunity

• Molecular Function
• Kinase, Receptor, Transferase, Tyrosine-protein kinase

• Cellular Localization
• Vesicles, Plasma membrane

• Introduction
• The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction

• Alternative Names
• C-FMS, CD115, CSFR, FMS

• Gene ID
• 1436

• UniProt ID
• P07333

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