Mouse Anti-DES Recombinant Antibody (clone 14G1C12)
CAT#: VS11-QX59
This product is a recombinant mouse antibody that recognizes Desim. This antibody can be used for the following applications: IHC, WB, ELISA.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18803/1161_A10_3_selected.jpg
Normal Tissue
Figure 2 High expression in skeletal muscle
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18803/43421_B_1_6_val_selected.jpg
Normal Tissue
Figure 3 Low expression in skin 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18803/43421_B_7_1_val_selected.jpg
Normal Tissue
Figure 4 High expression in heart muscle.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/34/1988_B_5_6_selected.jpg
Normal Tissue
Figure 5 Skeletal muscle
Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18803/43421_B_1_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HSkMC, LHCN-M2, NB-4, RH-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000175084-DES
❮
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Specifications
- Immunogen
- Recombinant DESMIN
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human DES
- Species Reactivity
- Human
- Clone
- 14G1C12
- Applications
- IHC, WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- 1 mg/mL (Please refer to the vial label for the specific concentration.)
- Buffer
- 0.2 μm filtered solution in PBS
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipped at 4°C.
Target
- Alternative Names
- Desmin; Intermediate Filament Protein; Cardiomyopathy, Dilated 1F (Autosomal Dominant); Mutant Desmin P.K241E; LGMD1D; LGMD1E
- Gene ID
- 1674
- UniProt ID
- P17661
- Long Name
- Desmin
- Sequence Similarities
- Belongs to the intermediate filament family.
- Cellular Localization
- Intermediate filaments
- Function
- Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "DES"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1487z | Mouse Anti-DES Recombinant Antibody (clone 25C5) | WB, ELISA, IHC | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0971 | Hi-Affi™ Rabbit Anti-DES Recombinant Antibody (clone DS971AB) | WB, IHC-P | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX325 | Mouse Anti-DES Recombinant Antibody (clone 290CT7.1.1) | WB | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY161 | Mouse Anti-NHP DES Recombinant Antibody (clone D33) | WB, IHC, IF | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC298 | CytoStream™ Rabbit Anti-DES Recombinant Antibody (VS13-YC298) | WB, ICC, IF, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1976 | Anti-DES Immunohistochemistry Kit | IHC | |
| VS-0525-XY1977 | Anti-Mouse DES Immunohistochemistry Kit | IHC | |
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