Human Anti-EPOR Recombinant Antibody (clone Ab12.6) (CAT#: HPAB-1693-FY)
This product is a recombinant antibody that recognizes EPOR. The monoclonal antibody Ab12.6 reacts with the epitope of EPOR.
Specific Inquiry
Activ
Figure 1 EPO-dependent cell proliferation activity of Ab12 variants correlates inversely with Kd.
Ab variants with faster off-rates (Abs 12.6, 12.70, and 12.56) stimulate the proliferation of EPO-responsive F36E human erythroleukemic cells more effectively than does Ab12.
Lacy, S. E., DeVries, P. J., Xie, N., Fung, E., Lesniewski, R. R., & Reilly, E. B. (2008). The potency of erythropoietin-mimic antibodies correlates inversely with affinity. The Journal of Immunology, 181(2), 1282-1287.
Activ
Figure 2 CFU-E colony forming activity of Ab12 variants correlates inversely with Kd.
Compared with Ab12, Abs with faster off-rates (12.6, 12.70, and 12.56) are more effective, whereas Ab12.17 with a slower offrate is less effective at supporting the formation of erythroid colonies from hematopoietic precursor cells. rHu- EPO was used as a positive control.
Lacy, S. E., DeVries, P. J., Xie, N., Fung, E., Lesniewski, R. R., & Reilly, E. B. (2008). The potency of erythropoietin-mimic antibodies correlates inversely with affinity. The Journal of Immunology, 181(2), 1282-1287.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human EPOR
- Species Reactivity
- Human
- Clone
- Ab12.6
- Applications
- FC, ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The EPOR antibody has been reported in applications of Activation, Flow Cytometry, Enzyme-linked Immunosorbent Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1451z | Mouse Anti-EPOR Recombinant Antibody (clone 37G2) | WB, ELISA, IF, IP | Mouse IgG3, κ |
| HPAB-0490-CN | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1) | ELISA, WB, ICC, IHC, IP | Mouse IgG |
| HPAB-0491-CN | Mouse Anti-EPOR Recombinant Antibody (clone 19.1.2) | ELISA, WB, ICC, IHC, IP | Mouse IgG |
| HPAB-1692-FY | Recombinant Human Anti-EPOR Antibody (Ab12) | Activ, FC, ELISA | Human IgG1 |
| HPAB-1694-FY | Human Anti-EPOR Recombinant Antibody (clone Ab12.56) | FC, ELISA | Human IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-040 | Human Anti-EPOR Recombinant Antibody (clone ABT-007); scFv Fragment | WB, FuncS | Human scFv |
| HPAB-1692-FY-F(E) | Recombinant Human Anti-EPOR Antibody scFv Fragment (Ab12) | FC, ELISA | Human scFv |
| HPAB-1693-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab12.6); scFv Fragment | FC, ELISA | Human scFv |
| HPAB-1694-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab12.56); scFv Fragment | FC, ELISA | Human scFv |
| HPAB-1306WJ-S(P) | Mouse Anti-EPOR Recombinant Antibody (clone 3G9); scFv Fragment | ELISA, WB, Agonist | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-007WM | Anti-Human EPOR Recombinant Antibody (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008WM | Anti-Human EPOR Recombinant Antibody (1E3) | ELISA, WB, FC | |
| TAB-009WM | Mouse Anti-EPOR Recombinant Antibody (TAB-009WM) | WB, FC | Mouse IgG |
| TAB-008WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (1E3) | ELISA, WB, FC | |
| TAB-009WM-S(P) | Mouse Anti-EPOR Recombinant Antibody; scFv Fragment (TAB-009WM-S(P)) | WB, FC | Mouse scFv |
| TAB-008WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (1E3) | ELISA, WB, FC |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-736CQ | Mouse Anti-EPOR Recombinant Antibody (clone CBL641) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1173 | Hi-Affi™ Rabbit Anti-EPOR Recombinant Antibody (clone DS1173AB) | IP, WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0490-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
| HPAB-0491-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 19.1.2); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
| HPAB-1692-FY-S(P) | Recombinant Human Anti-EPOR Antibody Fab Fragment (Ab12) | FC, ELISA | Human Fab |
| HPAB-1693-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab12.6); Fab Fragment | FC, ELISA | Human Fab |
| HPAB-1694-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab12.56); Fab Fragment | FC, ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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