Anti-FGFR4 Antibody Prodrug, Protease Activated (VS-1025-YC51)
CAT#: VS-1025-YC51
The Anti-FGFR4 Antibody Prodrug, Protease Activated (VS-1025-YC51) is an antibody prodrug comprised of a recombinant human antibody targeting FGFR4 protein of human, mouse, rat and monkey, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to FGFR4 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to FGFR4 effectively. FGFR4 is a receptor tyrosine kinase whose overexpression is linked to poor prognosis and aggressive disease in various cancers, including rhabdomyosarcoma and certain breast and liver cancers. Unlike other FGFRs, its role is often associated with promoting stemness, metastasis, and therapy resistance. Novel inhibitors are being developed to target its unique function.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human smooth muscle
Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27273/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human gall bladder
Immunohistochemical staining of human gall bladder shows strong cytoplasmic and membrane positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5196/ihc_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (CACO-2, Hep G2, RH-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160867-FGFR4
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human, Mouse, Rat and Monkey FGFR4
- Target
- FGFR4
- Species Reactivity
- Human, Mouse, Rat, Monkey
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1025-YC51. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "FGFR4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3383z | Mouse Anti-FGFR4 Recombinant Antibody (clone 31F7) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MOB-0739CT | Recombinant Mouse anti-Human FGFR4 Monoclonal antibody (NN0390-7I44) | WB | |
| HPAB-0054-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0054-LS) | Inhib | Human IgG |
| HPAB-0055-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0055-LS) | Inhib | Human IgG |
| HPAB-0056-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0056-LS) | Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-065WM | Mouse Anti-FGFR4 Recombinant Antibody (TAB-065WM) | ELISA, FC | Mouse IgG |
| TAB-067WM | Anti-Human FGFR4 Recombinant Antibody (F85-6C5) | IP, ELISA | |
| TAB-068WM | Mouse Anti-FGFR4 Recombinant Antibody (TAB-068WM) | ELISA, WB | Mouse IgG |
| TAB-069WM | Rat Anti-FGFR4 Recombinant Antibody (TAB-069WM) | ELISA, WB, FC, Inhib | Rat IgG |
| TAB-065WM-S(P) | Mouse Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-065WM-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066WM | Anti-Human FGFR4 Recombinant Antibody (XPA.48.056) | ELISA, FC | Human Antibody |
| TAB-066WM-S(P) | Anti-Human FGFR4 Recombinant Antibody scFv Fragment (XPA.48.056) | ELISA, FC | Human Antibody |
| TAB-066WM-F(E) | Anti-Human FGFR4 Recombinant Antibody Fab Fragment (XPA.48.056) | ELISA, FC | Human Antibody |
| TAB-384CQ | Human Anti-FGFR4 Recombinant Antibody (TAB-384CQ) | ELISA | Human IgG |
| TAB-384CQ-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-384CQ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1300 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone DS1300AB) | WB | Rabbit IgG |
| MOR-4575 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone TH87DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0054-LS-S(P)) | Inhib | Human scFv |
| HPAB-0055-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0055-LS-S(P)) | Inhib | Human scFv |
| HPAB-0056-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0056-LS-S(P)) | Inhib | Human scFv |
| HPAB-0057-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117); scFv Fragment | Inhib, ELISA, WB | Human scFv |
| HPAB-0058-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.148); scFv Fragment | Inhib, ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0054-LS-F(E)) | Inhib | Human Fab |
| HPAB-0055-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0055-LS-F(E)) | Inhib | Human Fab |
| HPAB-0056-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0056-LS-F(E)) | Inhib | Human Fab |
| HPAB-0057-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117); Fab Fragment | Inhib, ELISA, WB | Human Fab |
| HPAB-0058-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.148); Fab Fragment | Inhib, ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-028CN | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1) | ELISA, WB, FC, IHC, IP | Mouse IgG1 |
| NS-028CN-F(E) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); Fab Fragment | ELISA, WB, FC, IHC, IP | Mouse Fab |
| NS-028CN-S(P) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); scFv Fragment | ELISA, WB, FC, IHC, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY103 | AbPlus™ Anti-FGFR4 Magnetic Beads (F85-6C5) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC308 | Recombinant Anti-FGFR4 Vesicular Antibody, EV Displayed (VS-0425-YC308) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2545 | Anti-FGFR4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC134 | SmartAb™ Recombinant Anti-FGFR4 pH-dependent Antibody (Clone XPA.48.117) | Inhib, ELISA, WB | Human IgG |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: WB, ELISA, IF
Application: FC, IHC-Fr, IP, ELISA, Block
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, IF, Block, FuncS
Application: ELISA, WB, Microarray, Block
Application: ELISA, Block, WB, FC, IP
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
