Recombinant Anti-FGFR4 Vesicular Antibody, EV Displayed (VS-0425-YC308)

Name: Recombinant Anti-FGFR4 Vesicular Antibody, EV Displayed (VS-0425-YC308)
SKU: VS-0425-YC308
Rating: 5 (1 reviews)

CAT#: VS-0425-YC308

The Recombinant Anti-FGFR4 Vesicular Antibody, EV Displayed (VS-0425-YC308) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FGFR4-expressed cells or tissues. The FGFR4 is a tyrosine kinase receptor that is crucial for various regulatory functions, including cell differentiation and metabolism, affecting mitogenesis through FGFs.

Gene Expression

Normal Tissue Figure 1 IHC staining of human smooth muscle

Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27273/ihc_selected.jpg

Normal Tissue Figure 2 IHC staining of human gall bladder

Immunohistochemical staining of human gall bladder shows strong cytoplasmic and membrane positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/ihc_selected.jpg

Normal Tissue Figure 3 IHC staining of human prostate

Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5196/ihc_selected.jpg

Normal Tissue Figure 4 Colon

Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_3.jpg

Normal Tissue Figure 5 Liver

Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_4.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_7_5.jpg

Normal Tissue Figure 7 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_4_6.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (CACO-2, Hep G2, RH-30)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160867-FGFR4

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Recombinant Antibody

Application
ELISA, FC, Inhib, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
FGFR4

Host Animal
Rat

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
Protein A

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Fibroblast growth factor receptor 4

Molecular Function
Kinase, Receptor, Transferase, Tyrosine-protein kinase

Introduction
The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

Alternative Names
CD334, JTK2

Gene ID
2264

UniProt ID
P22455

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-0425-YC308.pdf

MSDS

MSDS - VS-0425-YC308.pdf

COA

Certificate of Analysis Lookup

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