AbPlus™ Anti-FGFR4 Magnetic Beads (F85-6C5)
CAT#: VS-0424-XY103
The AbPlus Anti-FGFR4 Magnetic Beads (F85-6C5) is an innovative affinity resin which is bound with anti-FGFR4 specific antibody (F85-6C5). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of FGFR4 protein under native and denaturing conditions.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human smooth muscle
Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27273/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human gall bladder
Immunohistochemical staining of human gall bladder shows strong cytoplasmic and membrane positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5196/ihc_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (CACO-2, Hep G2, RH-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160867-FGFR4
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-FGFR4 specific antibody (F85-6C5)
- Target
- FGFR4
- Target Species
- Human
- Antibody Clone
- F85-6C5
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
- Alternative Names
- FGFR4; fibroblast growth factor receptor 4; TKF; JTK2; CD334; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor
- Gene ID
- 2264
- UniProt ID
- B4DVP5
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "FGFR4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-065WM | Mouse Anti-FGFR4 Recombinant Antibody (TAB-065WM) | ELISA, FC | Mouse IgG |
| TAB-065WM-S(P) | Mouse Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-065WM-S(P)) | ELISA, FC | Mouse scFv |
| TAB-067WM-S(P) | Anti-Human FGFR4 Recombinant Antibody scFv Fragment (F85-6C5) | ELISA | |
| TAB-068WM-S(P) | Mouse Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-068WM-S(P)) | ELISA, WB | Mouse scFv |
| TAB-069WM-S(P) | Rat Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-069WM-S(P)) | ELISA, WB, FC | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066WM | Anti-Human FGFR4 Recombinant Antibody (XPA.48.056) | ELISA, FC | Human Antibody |
| TAB-066WM-F(E) | Anti-Human FGFR4 Recombinant Antibody Fab Fragment (XPA.48.056) | ELISA, FC | Human Antibody |
| TAB-384CQ | Human Anti-FGFR4 Recombinant Antibody (TAB-384CQ) | ELISA | Human IgG |
| TAB-384CQ-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-384CQ-S(P)) | ELISA | Human scFv |
| TAB-384CQ-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (TAB-384CQ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1300 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone DS1300AB) | WB | Rabbit IgG |
| MOR-4575 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone TH87DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0054-LS-S(P)) | Inhib | Human scFv |
| HPAB-0055-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0055-LS-S(P)) | Inhib | Human scFv |
| HPAB-0056-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0056-LS-S(P)) | Inhib | Human scFv |
| HPAB-0057-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117); scFv Fragment | Inhib, ELISA, WB | Human scFv |
| HPAB-0058-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.148); scFv Fragment | Inhib, ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0054-LS-F(E)) | Inhib | Human Fab |
| HPAB-0055-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0055-LS-F(E)) | Inhib | Human Fab |
| HPAB-0056-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0056-LS-F(E)) | Inhib | Human Fab |
| HPAB-0057-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117); Fab Fragment | Inhib, ELISA, WB | Human Fab |
| HPAB-0442-FY-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0442-FY-F(E)) | Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-028CN | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1) | ELISA, WB, FC, IHC, IP | Mouse IgG1 |
| NS-028CN-F(E) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); Fab Fragment | ELISA, WB, FC, IHC, IP | Mouse Fab |
| NS-028CN-S(P) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); scFv Fragment | ELISA, WB, FC, IHC, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0442-FY | Human Anti-FGFR4 Recombinant Antibody (HPAB-0442-FY) | Inhib | Human IgG |
| ZG-0344J | Mouse Anti-FGFR4 Recombinant Antibody (ZG-0344J) | WB, IF, ELISA | Mouse IgG |
| ZG-0345J | Mouse Anti-FGFR4 Recombinant Antibody (ZG-0345J) | WB, IHC, ELISA | Mouse IgG |
| VS7-HM948 | Mouse Anti-FGFR4 Recombinant Antibody (clone CBL284HM) | WB, IF, ICC, ELISA | Mouse IgG |
| VS7-HM949 | Mouse Anti-FGFR4 Recombinant Antibody (clone CBL285HM) | WB, IHC-p, IF, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC308 | Recombinant Anti-FGFR4 Vesicular Antibody, EV Displayed (VS-0425-YC308) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2545 | Anti-FGFR4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC134 | SmartAb™ Recombinant Anti-FGFR4 pH-dependent Antibody (Clone XPA.48.117) | Inhib, ELISA, WB | Human IgG |
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