Anti-FOLH1 (clone 2A10) Recombinant Antibody Coupled Liposome (VS-1024-FY305)
CAT#: VS-1024-FY305
Anti-PSMA antibody conjugated liposomes are designed to selectively target prostate cancer cells by binding to prostate-specific membrane antigen (PSMA), which is overexpressed on the surface of these cells. By encapsulating therapeutic agents within these liposomes, the targeted delivery system enhances the concentration of the drug directly at the tumor site while significantly reducing its distribution to healthy tissues, thereby minimizing systemic toxicity. This innovative approach not only aims to improve the efficacy of prostate cancer treatments but also holds the potential to transform the current therapeutic landscape by providing more personalized and effective care for patients battling this disease.
Gene Expression
Normal Tissue
Figure 1 Kidney
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
Normal Tissue
Figure 2 Prostate
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
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More Infomation
Specifications
- Potential Clinical Applications
- Prostate cancer
Product Composition
- Clone
- 2A10
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was developed to selectively bind to prostate-specific membrane antigen (PSMA). This monoclonal antibody's specificity for PSMA makes it an essential resource for the investigation of prostate cancer diagnosis and treatment. With its powerful binding properties, this antibody can assist researchers in exploring the implications of PSMA in tumor biology and potential therapeutic approaches.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- FOLH1
- Introduction
- Diseases associated with FOLH1 include Hyperhomocysteinemia and Lymph Node Carcinoma. Among its related pathways are Metabolism and GPCRs, class C metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is NAALAD2.
- Alternative Names
- Prostate-specific membrane antigen; PSMA
- Full Name
- Folate Hydrolase 1
- Gene ID
- 2346
- UniProt ID
- Q04609
- Sequence Similarities
- Belongs to the peptidase M28 family. M28B subfamily.
- Cellular Localization
- Cell membrane, Cytoplasm, Membrane
- Positive Control
- The positive control samples for this antibody include 3T3 lysates.
- Post Translation Modifications
- The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. (Q04609-FOLH1_HUMAN)
The N-terminus is blocked. (Q04609-FOLH1_HUMAN)
Glycosylation at Asn76, Asn336, Asn51, Asn121, Asn140, Asn153, Asn195, Asn459, Asn476, and Asn638 (NX_Q04609 [NX_Q04609-1])
Modification sites at PhosphoSitePlus (Q04609)
Glycosylation from GlyGen (Q04609) 13 sites
- Protein Refseq
- XP_011518260.2; XP_016872921.1; XP_016872922.1; XP_016872923.1; XP_047282634.1
- Function
- Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
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Datasheet
MSDS
COA
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See other products for "Clone 2A10"
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