Rabbit Anti-GYS1 (phospho S641) Recombinant Antibody (VS3-CJ641)
CAT#: VS3-CJ641
This product is a rabbit antibody that recognizes human, and mouse phospho-GYS1 (S641).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & microtubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41598/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human skeletal muscle
Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41598/91527_B_1_6_selected.jpg
Normal Tissue
Figure 3 Skeletal muscle.
High expression in skeletal muscle
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/ihc_selected.jpg
Normal Tissue
Figure 4 Heart muscle
Cardiomyocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_B_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_A_8_8.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_A_7_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7793/18859_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104812-GYS1
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Specifications
- Immunogen
- Synthetic peptide conjugated to Keyhole Limpet Haemocyanin (KLH)
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse phospho-GYS1 (S641)
- Species Reactivity
- Human, Mouse
- Applications
- WB, ICC, IHC, IP
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation.
Target
- Alternative Names
- GSY; GYS
- Gene ID
- 2997
- UniProt ID
- P13807
- Sequence Similarities
- Belongs to the glycosyltransferase 3 family.
- Cellular Localization
- Cytoplasm, Cytosol
- Post Translation Modifications
- Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity).
Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity).
Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.
- Protein Refseq
- NP_001155059.1; NP_002094.2
- Function
- Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GYS1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1550 | Rabbit Anti-GYS1 Recombinant Antibody (clone DS1550AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2329-CN | Rabbit Anti-GYS1 Recombinant Antibody (clone CBACN-620) | WB, IF, IHC, IP | Rabbit IgG |
| VS3-QX491 | Mouse Anti-GYS1 Recombinant Antibody (clone 2H1-C11-B9) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-CJ642 | Rabbit Anti-GYS1 Recombinant Antibody (VS3-CJ642) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| VS7-0425-WR5 | Mouse Anti-GYS1 Monoclonal Antibody (clone 3A7) | WB, FC | Mouse IgG1 |
| VS7-0425-WR6 | Mouse Anti-GYS1 Monoclonal Antibody (VS7-0425-WR6) | WB, FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY116 | AbPlus™ Anti-GYS1 Magnetic Beads (CBACN-248) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY983 | Anti-GYS1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2999 | Anti-Mouse GYS1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2998 | Anti-Human GYS1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC491 | CytoStream™ Rabbit Anti-GYS1 Recombinant Antibody (VS13-YC491) | WB, ICC, IF, IHC-P, FC, IP | Rabbit IgG |
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