Recombinant Human Anti-HA Antibody (FAMAB-0149YC)
CAT#: FAMAB-0149YC
The crystal structure of this antibody in complex with hemagglutinin revealed that the antibody binds to the globular head, spans a cleft formed by two hemagglutinin monomers in a hemagglutinin trimer, and cross-links them. It recognizes two peptide portions (sites L and R) and a glycan linked to asparagine at residue 285 using three complementarity-determining regions and framework 3 in the heavy chain. Binding of the antibody to sites L (residues 171 to 173, 239, and 240) and R (residues 91, 92, 270 to 273, 284, and 285) is mediated mainly by van der Waals contacts with the main chains of the peptides in these sites and secondarily by hydrogen bonds with a few side chains of conserved sequences in HA1. Furthermore, the glycan recognized by the mAb is conserved among H3N2 viruses. The antibody has the ability to prevent low-pH-induced conformational changes in hemagglutinin. The newly identified conserved epitope, including the glycan, should be immunogenic in humans and may induce production of broadly neutralizing antibodies against H3 viruses.
Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG
- Specificity
- H3N2 HA
- Species Reactivity
- H3N2
- Applications
- ELISA, Flow Cytometry, Neutralization
- Related Disease
- Influenza
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "HA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-076 | Recombinant Mouse Anti-IAV HA1 Antibody (26/9) | ELISA | IgG |
| PABC-078 | Recombinant Mouse Anti-IAV HA (T131I) Antibody | Neut | IgG |
| PABZ-078 | Recombinant Mouse Anti-IAV HA heptapeptide (DVPDYAS) Antibody (17/9) | ELISA | IgG |
| FAMAB-0150YC | Recombinant Human Anti-HA Antibody (FAMAB-0150YC) | FC, Neut | Human IgG |
| FAMAB-0151YC | Recombinant Human Anti-HA Antibody (FAMAB-0151YC) | FC, Neut | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-051 | Recombinant Mouse Anti-H3N2 NA Antibody scFv Fragment (Mem5) | WB, ELISA | scFv |
| PSBZ-076 | Recombinant Mouse Anti-IAV HA1 Antibody scFv Fragment (26/9) | ELISA | scFv |
| FAMAB-0149-YC-S(P) | Recombinant Human Anti-HA Antibody scFv Fragment (FAMAB-0149-YC-S(P)) | ELISA, FC, Neut | Human scFv |
| FAMAB-0150-YC-S(P) | Recombinant Human Anti-HA Antibody scFv Fragment (FAMAB-0150-YC-S(P)) | FC, Neut | Human scFv |
| FAMAB-0151-YC-S(P) | Recombinant Human Anti-HA Antibody scFv Fragment (FAMAB-0151-YC-S(P)) | FC, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-241CT | Anti-IAV HA Recombinant Antibody (D1-1) | WB, FC, IP, Inhib | Human antibody |
| MRO-242CT | Anti-IAV HA Recombinant Antibody (D1-2) | WB, FC, IP, Inhib | Human antibody |
| MRO-243CT | Anti-IAV HA Recombinant Antibody (D1-3) | WB, FC, IP, Inhib | Human antibody |
| MRO-244CT | Anti-IAV HA Recombinant Antibody (D1-4) | WB, FC, IP, Inhib | Human antibody |
| MRO-245CT | Anti-IAV HA Recombinant Antibody (D1-5) | WB, FC, IP, Inhib | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-301CT | Anti-IAV HA Recombinant Antibody (3741 ) | WB, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-282CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (49A12) | WB, ELISA, IHC, Neut | |
| MRO-283CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (21D12) | WB, ELISA, IHC, Neut | |
| MRO-284CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (Clone 81) | WB, ELISA | |
| MRO-285CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (Clone 11) | WB, ELISA | |
| MRO-286CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (Clone 2) | WB, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-070-S (P) | Recombinant Mouse Anti-HA1 Antibody scFv Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4209 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI287DS) | ELISA, ICC, IF, IF, FC | IgG |
| MOR-4210 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI288DS) | ELISA, ICC, IF, IF, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0254-YC-F(E) | Recombinant Mouse Anti-HA Antibody Fab Fragment (H153-70A12) | ELISA | Mouse Fab |
| FAMAB-0277-YC-F(E) | Recombinant Mouse Anti-HA Antibody Fab Fragment (T1-107) | ELISA | Mouse Fab |
| HPAB-M0099-YC-F(E) | Human Anti-HA Recombinant Antibody Fab Fragment (HPAB-M0099-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-M0100-YC-F(E) | Human Anti-HA Recombinant Antibody Fab Fragment (HPAB-M0100-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-M0101-YC-F(E) | Human Anti-HA Recombinant Antibody Fab Fragment (HPAB-M0101-YC-F(E)) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0765 | PE-DRB1*04:01/Influenza HA (PKYVKQNTLKLAT) MHC Tetramer | FCM, IHC | |
| MHC-CN0766 | APC-DRB1*04:01/Influenza HA (PKYVKQNTLKLAT) MHC Tetramer | FCM, IHC | |
| MHC-CN0767 | FITC-DRB1*04:01/Influenza HA (PKYVKQNTLKLAT) MHC Tetramer | FCM, IHC | |
| MHC-CN0768 | DRB1*04:01/Influenza HA (PKYVKQNTLKLAT) MHC Tetramer | FCM, IHC | |
| MHC-YF1346 | FITC-DRB1*04:02/Human HA (PKYVKQNTLKLAT) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1169-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1169-FY) | Neut | Llama VHH |
| HPAB-1170-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1170-FY) | Neut | Llama VHH |
| HPAB-1171-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1171-FY) | Neut | Llama VHH |
| HPAB-1172-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1172-FY) | Neut | Llama VHH |
| HPAB-1173-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1173-FY) | Neut | Llama VHH |
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