Provided is a PR8-specific antibody, which binds to the PR8 HA (which contains Asp at residue 225).
Wang, Lixue, et al. "Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles." Nature Communications 14.1 (2023): 3366.
This study focuses on the bioinspired engineering of fusogen and targeting moiety equipped nanovesicles (eFT-CNVs) to enhance drug delivery efficiency. The researchers developed eFT-CNVs by mechanically extruding genetically modified donor cells to produce high-yield and consistent nanovesicles. These engineered vesicles co-express a fusogen derived from the Sindbis virus and an anti-GPC3 single-chain variable fragment (scFv), enabling them to selectively bind to GPC3-overexpressing cancer cells and facilitate efficient cytosolic drug delivery through membrane fusion. The study demonstrated that eFT-CNVs significantly improve the treatment efficacy of drugs targeting cytosolic components, suggesting that these nanovesicles hold promise for advancing nanomedicine and precision medicine.
Creative Biolabs contributed to this research by providing the anti-HA antibody Fab fragment (Cat# FAMAB-0254-YC-F(E)). This antibody was essential for estimating the concentration of fusogen on eFT-CNVs, which was crucial for evaluating the efficiency of membrane fusion and drug delivery. By enabling precise quantification of fusogen molecules, the anti-HA antibody from Creative Biolabs supported the researchers in optimizing the design and functionality of the bioengineered nanovesicles, thereby facilitating the study's goal of enhancing targeted drug delivery systems.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-203 | Recombinant Human Anti-IAV HA Antibody (3.1) | WB, ELISA, FuncS | IgG |
PABL-204 | Recombinant Human Anti-IAV HA Antibody (39.29) | Neut, FuncS | IgG |
PABL-205 | Recombinant Human Anti-IAV HA Antibody (1957) | WB, Neut, FuncS | IgG |
PABL-206 | Recombinant Human Anti-IAV HA Antibody (1F1) | WB, ELISA, FuncS | IgG |
PABL-207 | Recombinant Human Anti-IAV HA Antibody (5J8) | FuncS | IgG |
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# FAMAB-0254-YC-F(E), RRID: AB_3111324)
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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